Spousal concordance for alcohol dependence: Evidence for assortative mating or spousal interaction effects?
Spousal concordance for alcohol dependence: Evidence for assortative mating or spousal interaction effects?
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DOI：
10.1111/j.1530-0277.2007.00356.x
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发表时间：
2007-05-01
影响因子：
3.2
通讯作者：
Martin, Nicholas G.
中科院分区：
文献类型：
--
作者：
Grant, Julia D.;Heath, Andrew C.;Martin, Nicholas G.
背景资料：酒精依赖（AD）是最常见的精神疾病之一，并影响问题饮酒者，他们的家庭成员和整个社会的健康和福祉。虽然以前的研究一直表明，遗传因素有助于方差的风险，AD，很少有人注意到非随机交配的AD。当一个可遗传的特征发生选择性交配时，配偶在遗传上是相关的，后代从父母双方接受高风险基因的风险增加。本分析的主要目标是测试假设的来源（S）和规模的配偶协会AD使用双配偶design.Methods：DSM-IV AD（无聚类标准）通过电话采访进行了评估，为5,974双胞胎成员的老年队列的澳大利亚双胞胎登记（出生于1902年至1964年）和3,814配偶的双胞胎。定量遗传模型被用来确定在何种程度上的AD风险的变异是由遗传因素的影响，AD的配偶协会的程度，以及该协会是否可归因于强迫交配，互惠配偶的相互作用，或两者兼而有之processs.Results：遗传因素解释了49%的方差在AD的风险。没有证据表明配偶的相互作用效应、评分者的偏倚程度或双胞胎配偶AD报告与配偶AD表型之间存在性别差异。无论是选择性交配参数或配偶相互作用参数可以从模型中删除，而不会显着减少拟合，但两者不能同时下降，这表明缺乏权力来区分这2个原因的配偶相关性。当两种效应都包括在模型中时，配偶相关性为0.29，选择性交配系数为0.45（即，“同类结婚同类”），配偶相互作用系数倒数为-0.10（即，在控制选型交配后，配偶互动的额外影响具有轻微的保护作用）。结论：这些分析提供了与AD显着配偶关联的证据，选型交配增加了配偶相似性，而配偶互动效应在控制选型交配后降低了配偶相似性。虽然遗传影响是适度的，但强迫交配导致后代暴露于2个酗酒父母和相关的有害环境后遗症的比例增加，并增加后代从父母双方遗传高危基因的可能性。
Background: Alcohol dependence (AD) is among the most common psychiatric disorders, and impacts the health and well-being of problem drinkers, their family members, and society as a whole. Although previous research has consistently indicated that genetic factors contribute to variance in risk for AD, little attention has been paid to nonrandom mating for AD. When assortative mating occurs for a heritable trait, spouses are genetically correlated and offspring are at increased risk of receiving high-risk genes from both parents. The primary goal of the present analyses is to test hypotheses about the source(s) and magnitude of spousal associations for AD using a twin-spouse design.Methods: DSM-IV AD (without the clustering criterion) was assessed via telephone interview for 5,974 twin members of an older cohort of the Australian Twin Register (born 1902-1964) and 3,814 spouses of the twins. Quantitative genetic modeling was used to determine the extent to which variability in risk for AD was influenced by genetic factors, the extent of spousal association for AD, and whether the association was attributable to assortative mating, reciprocal spousal interaction, or both processes.Results: Genetic factors explained 49% of the variance in risk for AD. There was no evidence of gender differences in the spousal interaction effect, the degree of rater bias, or the association between the twin's report of spouse AD and the spouse's AD phenotype. Either the assortative mating parameter or the spousal interaction parameter could be removed from the model without a significant decrement in fit, but both could not be dropped simultaneously, suggesting a lack of power to differentiate between these 2 causes of spousal correlation. When both effects were included in the model, the spousal correlation was 0.29, the assortative mating coefficient was 0.45 (i.e., "like marries like"), and the reciprocal spousal interaction coefficient was -0.10 (i.e., after controlling for assortative mating, the additional impact of spousal interactions is slightly protective).Conclusions: These analyses provide evidence of significant spousal associations for AD, with assortative mating increasing spouse similarity and spousal interaction effects decreasing it after controlling for assortative mating. Although the genetic impact is modest, assortative mating results in an increased proportion of offspring exposed to 2 alcoholic parents and the associated detrimental environmental sequelae, and increases the likelihood of offspring inheriting high-risk genes from both parents.