Regular physical activity modifies smoking-related lung function decline and reduces risk of chronic obstructive pulmonary disease -: A population-based cohort study
Regular physical activity modifies smoking-related lung function decline and reduces risk of chronic obstructive pulmonary disease -: A population-based cohort study
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DOI：
10.1164/rccm.200607-896oc
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发表时间：
2007-03-01
影响因子：
24.7
通讯作者：
Anto, Josep M.
中科院分区：
文献类型：
--
作者：
Garcia-Aymerich, Judith;Lange, Peter;Anto, Josep M.
依据：我们以前曾报道过规律的体力活动可以降低慢性阻塞性肺疾病（COPD）加重的风险。我们假设更高水平的规律体力活动可以通过改变吸烟相关的肺功能下降来降低COPD的风险。目的：评估规律体力活动与FEV 1和FVC下降和COPD风险之间的纵向关联。方法：基于人口的抽样1981-1983年，在哥本哈根招募了6，790例受试者，并对他们的体力活动、吸烟、肺功能和其他协变量进行了评估，一直持续到1991-1994年。基线和随访之间的平均体力活动水平分为“低”、“中”和“高”。“FEV 1和FVC下降率以毫升/年表示。COPD定义为FEV 1/FVC
Rationale: We have previously reported that regular physical activity reduces risk of chronic obstructive pulmonary disease (COPD) exacerbation. We hypothesized that higher levels of regular physical activity could reduce the risk of COPD by modifying smoking-related lung function decline.Objective: To estimate the longitudinal association between regular physical activity and FEV1 and FVC decline and COPD risk.Methods: A population-based sample (n = 6,790) was recruited and assessed with respect to physical activity, smoking, lung function, and other covariates, in Copenhagen in 1981-1983, and followed until 1991-1994. Mean level of physical activity between baseline and follow-up was classified into "low," "moderate," and "high." FEV1 and FVC decline rates were expressed as milliliters per year. COPD was defined as FEV1/FVC