Challenges for detection of neuronal currents by MRI
Challenges for detection of neuronal currents by MRI
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DOI：
10.1016/j.mri.2005.12.027
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发表时间：
2006-05-01
影响因子：
2.5
通讯作者：
Maraviglia, B
中科院分区：
文献类型：
--
作者：
Hagberg, GE;Bianciardi, M;Maraviglia, B
神经元电流磁共振成像(NC-MRI)是一种直接成像神经元电流引起的磁场变化的成像方法，具有较高的时间和空间分辨率。一种可行的NC-MRI方法将对人类大脑功能的研究和癫痫领域的临床应用，特别是对致痫灶的无创性术前标测具有重要意义。回顾了NC-MRI的基本问题，并在此背景下描述了该方法未来发展的挑战。特别是，给出了信号产生的模型的概述，并描述了不同来源的神经元电流的起源和生理。展望了通过电磁场映射来预测神经元电流，并将这些信息用于NC-MRI的先验和后验。描述了通过最小化二次血流动力学和代谢影响来提高NC-MRI的特异性的方法，以及优化NC-MRI方法以提高检测极限的方法。在这些分类中描述了以前发表的工作，并提出了NC-MRI的未来发展方向。(C)2006 Elsevier Inc.保留所有权利。
Neuronal current MRI (nc-MRI) is an imaging method that directly maps magnetic field changes caused by neuronal currents with, at the same time, a high spatial and temporal resolution. A viable nc-MRI method would be of great benefit, both for the study of human brain function and for clinical applications in the field of epilepsy, especially for the noninvasive presurgical mapping of epileptogenic foci. A survey of fundamental issues in nc-MRI is reviewed, and challenges for future developments of the method are described within this context. Particularly, an overview of the models for signal generation is given, and the origin and physiology of different sources of neuronal currents are described. Prospects for predicting neuronal currents by electromagnetic field mapping and using this information, both a priori and a posteriori, for nc-MRI are considered. Ways of increasing specificity in nc-MRI by minimizing secondary hemodynamic and metabolic effects are described as well as means of optimizing the nc-MRI method for pushing the detection limit. Previously published works are described within these categories and future directions for nc-MRI are proposed. (c) 2006 Elsevier Inc. All rights reserved.