Overlapping and parallel cerebello-cerebral networks contributing to sensorimotor control: An intrinsic functional connectivity study
Overlapping and parallel cerebello-cerebral networks contributing to sensorimotor control: An intrinsic functional connectivity study
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DOI：
10.1016/j.neuroimage.2013.07.027
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发表时间：
2013-12-01
期刊：
影响因子：
5.7
通讯作者：
Margulies, Daniel S.
中科院分区：
文献类型：
--
作者：
Kipping, Judy A.;Grodd, Wolfgang;Margulies, Daniel S.
与大脑的感觉运动控制区相协调，小脑在各种与感觉运动相关的任务中显示出不同的激活模式。然而，参与动作控制的复杂和不同种类的小脑-大脑系统的空间细节和范围仍然不确定。在这项研究中，我们使用内在功能连接性(IFC)来检测五个小脑小叶(I-IV、V、VI和VIIIa/b)的小脑-大脑网络，这些小叶已经被经验地识别为构成感觉运动过程的功能基础。精确的小脑种子区选择使我们能够识别一个由初级感觉运动区和辅助运动区组成的网络(I-V)，由前额区、运动前区、枕颞区和顶下区组成的网络(VI)，以及涉及运动前区和顶上区、颞顶交界区和枕颞区的两个大体重叠的网络(VIIIa/b)。所有网络均累及内侧前额叶/扣带回皮质。这些脑簇被用于偏相关分析，以系统地绘制整个小脑的大脑连接图。我们在情感和认知控制、感觉运动、多感觉系统和执行/语言系统的框架内讨论这些发现。在小脑内，我们发现大脑-小脑系统似乎平行运行，如额叶、顶叶、感觉运动、扣带和枕颞区的不同小叶下功能地形图所示。然而，所有区域在两个半球都显示出不同程度的重叠连接。这两种分析的结果都表明，小脑小叶的不同小球下部分可能在初级或高级感觉运动加工的不同方面起主导作用。这种系统级别的小脑组织为小脑-大脑相互作用提供了更详细的结构，这有助于我们理解复杂的运动行为。(C)2013 Elsevier Inc.保留所有权利。
In concert with sensorimotor control areas of the cerebrum, the cerebellum shows differential activation patterns during a variety of sensorimotor-related tasks. However, the spatial details and extent of the complex and heterogeneous cerebello-cerebral systems involved in action control remain uncertain. In this study, we use intrinsic functional connectivity (iFC) to examine cerebello-cerebral networks of five cerebellar lobules (I-IV, V, VI, and VIIIa/b) that have been empirically identified to form the functional basis of sensorimotor processes. A refined cerebellar seed-region selection allowed us to identify a network of primary sensorimotor and supplementary motor areas (I-V), a network of prefrontal, premotor, occipito-temporal and inferior-parietal regions (VI), and two largely overlapping networks involving premotor and superior parietal regions, the temporo-parietal junction as well as occipito-temporal regions (VIIIa/b). All networks involved the medial prefrontal/cingulate cortex. These cerebral clusters were used in a partial correlation analysis to systematically map cerebral connectivity throughout the entire cerebellum. We discuss these findings in the framework of affective and cognitive control, sensorimotor, multisensory systems, and executive/language systems. Within the cerebellum we found that cerebro-cerebellar systems seem to run in parallel, as indicated by distinct sublobular functional topography of prefrontal, parietal, sensorimotor, cingulate, and occipito-temporal regions. However, all areas showed overlapping connectivity to various degrees in both hemispheres. The results of both analyses demonstrate that different sublobular parts of the cerebellar lobules may dominate in different aspects of primary or higher-order sensorimotor processing. This systems-level cerebellar organization provides a more detailed structure for cerebello-cerebral interaction which contributes to our understanding of complex motor behavior. (C) 2013 Elsevier Inc. All rights reserved.