STRONG ASSOCIATION BETWEEN CAPSULAR TYPE AND VIRULENCE FOR MICE AMONG HUMAN ISOLATES OF STREPTOCOCCUS-PNEUMONIAE
STRONG ASSOCIATION BETWEEN CAPSULAR TYPE AND VIRULENCE FOR MICE AMONG HUMAN ISOLATES OF STREPTOCOCCUS-PNEUMONIAE
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DOI：
10.1128/iai.60.1.111-116.1992
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发表时间：
1992-01-01
影响因子：
3.1
通讯作者：
YOTHER, J
中科院分区：
文献类型：
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作者：
BRILES, DE;CRAIN, MJ;YOTHER, J
用69株新鲜人源肺炎链球菌分离株，研究了荚膜类型与小鼠毒力的关系。 这些分离株代表了八种囊膜类型或组。 PspA（肺炎球菌表面蛋白A）的血清学和分子量的差异表明，菌株的克隆不同。 小鼠用所有69种分离物的无菌盐溶液中的洗涤细菌静脉内感染。 还对28株分离株进行了腹膜内注射，以比较静脉内和腹膜内途径。 除少数例外情况外，菌株通过两种途径引起致命感染的能力一致。 约30%的分离物对小鼠有毒性。 分离株杀死小鼠的能力和接种与死亡之间的时间长度与荚膜类型密切相关。 所有4型分离株、40%的3型分离株和60%的6组分离株对小鼠具有毒性; 1型分离株具有轻微毒性;所有14、19和23型或组分离株均无毒力。 感染6型或1型肺炎球菌的小鼠的死亡时间通常长于感染3型或4型肺炎球菌的小鼠。 临床诊断和组织来源与致病力无关。
The relationship between capsular type and virulence for mice was examined with 69 fresh human isolates of Streptococcus pneumoniae. These isolates represented eight capsular types or groups. Serologic and molecular weight differences in PspA (pneumococcal surface protein A) indicated that the strains were clonally distinct. Mice were infected intravenously with washed bacteria of all 69 isolates in sterile salt solutions. Twenty-eight of the isolates were also injected intraperitoneally to permit comparisons between the intravenous and intraperitoneal routes. With a few exceptions, there was concordance between the ability of strains to cause fatal infections by the two routes. About 30% of the 69 isolates were virulent for mice. The abilities of the isolates to kill mice and the length of time between inoculation and death were strongly associated with capsular type. All type 4 isolates, 40% of type 3 isolates, and 60% of group 6 isolates were virulent for mice; type 1 isolates were marginally virulent; and all type or group 14, 19, and 23 isolates were avirulent. Times to death were generally longer for mice infected with group 6 or type 1 than for those infected with type 3 or 4 pneumococci. There was no relationship between clinical diagnosis or tissue source of the isolates and virulence for mice.