Marine Antimicrobial Peptides: A Promising Source of New Generation Antibiotics and Other Bio-active Molecules
Marine Antimicrobial Peptides: A Promising Source of New Generation Antibiotics and Other Bio-active Molecules
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DOI：
10.1007/s10989-018-9789-3
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发表时间：
2019-12-01
影响因子：
2.5
通讯作者：
Munoz-Garay, Carlos
中科院分区：
文献类型：
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作者：
Bertrand, Brandt;Munoz-Garay, Carlos
多重耐药病原微生物已造成全球健康危机。这种耐药性的出现是由于常规抗生素的不当使用。因此，科学界被迫寻找新的抗菌药物。海洋生态系统中有各种各样的生物和微生物，它们相互作用，因此必须保护自己免受病原体的侵害。因此，它们具有广泛的不同机制和生物分子，使它们能够在自然环境中生存。这些分子中有抗微生物肽。对这些天然抗生素的研究由于其在治疗几种传染病方面的潜力而引起了广泛的关注。多年来，对这些分子的研究一直集中在陆地环境中，然而，目前的趋势是转向海洋生态系统，由于其巨大的未开发的多样性，沿着新分子和新活性的潜在发现。
Multidrug resistant pathogenic microorganisms have created a global health crisis. This resistance emerged due to the improper use of conventional antibiotics. As a result, the scientific community has been forced to search for new antimicrobial drugs. Marine ecosystems have an immense diversity of organisms and microorganisms that interact with each other, and thus, have to defend themselves against pathogens. Therefore, they present a wide repertoire of different mechanisms and biomolecules, which enables them to survive in their natural environment. Among these molecules are the antimicrobial peptides. Research on these natural antibiotics has gained a lot of attention due to their potential in the treatment of several infectious diseases. The search for these molecules over the years has focused on terrestrial environments, however, the current trend is moving toward marine ecosystems, due to their vast unexplored diversity, along with the potential discovery of new molecules and novel activities.