Helicobacter pylori infection associated with high HbA1c and type 2 diabetes
Helicobacter pylori infection associated with high HbA1c and type 2 diabetes
复制标题
DOI：
10.1111/eci.12124
复制
发表时间：
2013-09-01
影响因子：
5.5
通讯作者：
Wu, Deng-Chyang
中科院分区：
文献类型：
--
作者：
Hsieh, Ming-Chia;Wang, Sophie S. W.;Wu, Deng-Chyang
背景：虽然慢性幽门螺杆菌感染与2型糖尿病之间的关系已经被提出，但研究结果并不一致。本研究评估了慢性H。pylori感染与血糖调节的关系。幽门螺杆菌感染状况的参与者招募从消化科门诊在我院。在基线时，我们进行了血液检查，包括空腹血糖，胰岛素，糖化血红蛋白A1 c（HbA 1c）和其他生化指标。胰岛素抵抗和胰岛β细胞功能分别采用稳态模型（HOMA-IR和HOMA-B）评估。那些有H。pylori感染者血清HbA 1c水平高于非pylori感染者（5.78% vs. 5.69%，P = 0.01），HOMA-B水平低于非pylori感染者（53.85 ± 38.43 vs. 60.64 ± 43.40，P = 0.009）。2型糖尿病的患病率也明显较高（8.97%对5.57%，P = 0.02）。慢性H.结论长期H.pylori感染与中国人群HbA 1c水平升高和胰岛素分泌降低密切相关。适当筛查幽门螺杆菌感染并定期监测血糖和HbA 1c水平可能对早期发现血糖失调和预防2型糖尿病有效。
Background Although the association between chronic Helicobacter pylori infection and type 2 diabetes has been suggested, findings have been inconsistent. This study evaluated the association between chronic H. pylori infection and glucose regulation.Materials and Methods We evaluated H. pylori infection status of participants recruited from the gastroenterology clinic at our hospital. At baseline, we performed blood tests including fasting plasma glucose, insulin, glycated haemoglobin A1c (HbA1c) and other biochemical measurements. Insulin resistance and beta-cell function were assessed by homoeostasis model assessment (HOMA-IR and HOMA-B, respectively).Results A total of 2070 participants were recruited. Those who had H. pylori infections had higher serum HbA1c levels and lower HOMA-B than those who did not (5.78% vs. 5.69%, P = 0.01 and 53.85 + 38.43 vs. 60.64 + 43.40, P = 0.009, respectively). They also had a significantly higher prevalence of type 2 diabetes (8.97% vs. 5.57%, P = 002). Chronic H. pylori infection was significantly associated with high levels of HbA1c and type 2 diabetes in participants above 65 years old (P = 0.001) and decreased insulin secretion and sensitivity in those under 45 years (P = 0.05).Conclusions Long-term H.pylori infection is significantly associated with high levels of HbA1c and decreased insulin secretion in this Chinese population. Proper screening for H.pylori infection combined with regular monitoring of blood glucose and HbA1c levels might be effective for the early detection of glucose dysregulation and prevention of type 2 diabetes.