Warner-Lambert/Parke-Davis award lecture. Cytokine-mediated activation of vascular endothelium. Physiology and pathology.
Warner-Lambert/Parke-Davis award lecture. Cytokine-mediated activation of vascular endothelium. Physiology and pathology.
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发表时间：
1988-12
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通讯作者：
J. Pober
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作者：
J. Pober
内皮细胞活化的概念在理解内皮细胞功能方面非常有用。20世纪60年代激活的形态学定义已被20世纪80年代的细胞生物学定义所取代，但最近的研究表明，这些现象是同一过程的两个方面。此外，内皮细胞活化是一种有益的反应，而损伤和功能障碍是一种有害的反应，这一最初的区分已经变得更加复杂，因为临床研究表明，活化可以产生功能障碍，无论有无损伤。最重要的是，正如我们的体内研究表明的那样，激活的概念是一个可测试的假设，因为现代免疫化学和分子生物学技术已经被用来弥合体外培养实验和基于患者的临床研究之间的差距。
The concept of endothelial cell activation has been extremely useful in understanding endothelial cell function. The morphologic definition of activation from the 1960s has been replaced by a cell biologic definition in the 1980s, but recent studies have suggested that these phenomena are two aspects of the same processes. Moreover, the initial distinction of endothelial cell activation, a beneficial reaction, from injury and dysfunction, a harmful sequence, has become more complex as clinical studies have revealed that activation can produce dysfunction, with or without injury. Most importantly, as our in vivo studies indicate, the concept of activation is a testable hypothesis, as modern immunochemical and molecular biologic techniques have been employed to bridge the gap between in vitro culture experiments and patient-based clinical research.