Immune privilege and angiogenic privilege of the cornea.
Immune privilege and angiogenic privilege of the cornea.
复制标题
DOI：
10.1159/000099253
复制
发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Cursiefen, Claus
中科院分区：
文献类型：
--
作者：
Cursiefen, Claus
角膜是眼睛的透明窗口，角膜透明度对良好视力至关重要。角膜内的炎症反应不仅会导致组织破坏和瘢痕形成，而且还与角膜中的血管生成和淋巴管生成有关。这两种炎症相关过程都会干扰角膜透明度并导致角膜失明。在进化过程中，角膜已经发展出预防和调节炎症和血管生成反应的机制。角膜通常缺乏血管和淋巴管，并积极维持这种无血管性，这一事实被称为“角膜血管生成障碍”。另一方面，角膜的“免疫排斥”表明角膜是一个免疫豁免的部位和组织，使组织学不相容的角膜移植获得了非凡的成功。最近的证据表明，在维持角膜“血管生成”和“免疫抑制”的分子机制中存在相当大的重叠。
The cornea is the transparent window of the eye and corneal transparency is essential for good vision. Inflammatory reactions within the cornea cannot only cause tissue destruction and scar formation, but are also associated with angiogenesis and lymphangiogenesis in the cornea. Both inflammation-associated processes interfere with corneal transparency and cause corneal blindness. During evolution the cornea has developed mechanisms for preventing and modulating inflammatory and angiogenic reactions. The fact that the cornea is normally devoid of both blood and lymphatic vessels and actively maintains this avascularity has been termed 'corneal angiogenic privilege'. Corneal 'immune privilege', on the other hand, indicates that the cornea is an immune-privileged site and tissue, enabling the extraordinary success of histologically incompatible corneal transplantation. Recent evidence indicates that there is considerable overlap in the molecular mechanisms maintaining corneal 'angiogenic' and 'immune privilege'.