HIV-Exposed Seronegative Commercial Sex Workers Show a Quiescent Phenotype in the CD4+ T Cell Compartment and Reduced Expression of HIV-Dependent Host Factors
HIV-Exposed Seronegative Commercial Sex Workers Show a Quiescent Phenotype in the CD4+ T Cell Compartment and Reduced Expression of HIV-Dependent Host Factors
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DOI：
10.1086/655968
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发表时间：
2010-11-01
影响因子：
6.4
通讯作者：
Fowke, Keith R.
中科院分区：
文献类型：
--
作者：
McLaren, Paul J.;Ball, T. Blake;Fowke, Keith R.
对人类免疫缺陷病毒（HIV）暴露血清阴性个体的研究对于疫苗设计至关重要。在本研究中，我们证明了暴露于HIV血清阴性的商业性工作者产生的促炎细胞因子水平低于HIV阴性对照组。我们还发现，暴露于HIV血清阴性的商业性工作者的CD4（+）T细胞具有特征性的较低基因表达水平，这可以在差异表达的基因和对HIV复制至关重要的系统中看到，例如T细胞受体途径和先前确定的HIV依赖因子。这种明显降低的激活导致我们称之为“免疫静止”的现象，这可能有助于宿主对HIV的抵抗。
Studies of human immunodeficiency virus (HIV)-exposed seronegative individuals are crucial to inform vaccine design. In the present study we demonstrated that HIV-exposed seronegative commercial sex workers produce lower levels of proinflammatory cytokines at baseline than HIV-negative control subjects. We also showed that CD4(+) T cells of HIV-exposed seronegative commercial sex workers have a characteristically lower level of gene expression that can be seen in differentially expressed genes and systems crucial for HIV replication, such as the T cell receptor pathway and previously identified HIV dependency factors. This apparent lowered activation results in a phenomenon we term "immune quiescence," which may contribute to host resistance to HIV.