Differential Reward Coding in the Subdivisions of the Primate Caudate during an Oculomotor Task
Differential Reward Coding in the Subdivisions of the Primate Caudate during an Oculomotor Task
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DOI：
10.1523/jneurosci.1518-12.2012
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发表时间：
2012-11-07
影响因子：
5.3
通讯作者：
Nakahara, Hiroyuki
中科院分区：
文献类型：
--
作者：
Nakamura, Kae;Santos, Gustavo S.;Nakahara, Hiroyuki
基底神经节在奖赏导向行为中起着关键作用。纹状体是基底神经节的输入通道，由与不同的皮质和皮质下区域地形连接的分区组成。为了测试奖励信息是否在纹状体的不同部位进行差异化处理，我们比较了执行不对称奖励视觉任务的猴子尾状核背外侧-腹内侧轴上与奖励相关的神经元活动沿着。在一个给定的区块中，一个位置上的目标与大奖励相关联，而另一个目标与小奖励相关联。目标位置-奖励值列联在区组之间切换。我们发现以下内容：（1）反映区块奖励偶然性的活动在视觉目标出现之前出现，并且在背侧尾状核中更普遍，而不是中央和腹侧尾状核;（2）与当前试验的奖励大小正相关的活动是明显的，特别是在奖励传递之后，并且在腹侧和中央尾状核中更普遍，而不是背侧尾状核;（3）背侧尾状核和中央尾状核的活动明显受到对先前试验结果的记忆的调节。这种多重奖赏信息与目标方向信息一起主要由单个尾状核神经元来表示，而不同的奖赏信息则由具有不同电生理特性的尾状核亚群来表示。例如，在一个实施例中，基线放电和尖峰宽度。这些结果表明，不同的奖励信息的并行处理由基底神经节的外部连接和内在属性所定义的细分。
The basal ganglia play a pivotal role in reward-oriented behavior. The striatum, an input channel of the basal ganglia, is composed of subdivisions that are topographically connected with different cortical and subcortical areas. To test whether reward information is differentially processed in the different parts of the striatum, we compared reward-related neuronal activity along the dorsolateral-ventromedial axis in the caudate nucleus of monkeys performing an asymmetrically rewarded oculomotor task. In a given block, a target in one position was associated with a large reward, whereas the other target was associated with a small reward. The target position-reward value contingency was switched between blocks. We found the following: (1) activity that reflected the block-wise reward contingency emerged before the appearance of a visual target, and it was more prevalent in the dorsal, rather than central and ventral, caudate; (2) activity that was positively related to the reward size of the current trial was evident, especially after reward delivery, and it was more prevalent in the ventral and central, rather than dorsal, caudate; and (3) activity that was modulated by the memory of the outcomes of the previous trials was evident in the dorsal and central caudate. This multiple reward information, together with the target-direction information, was represented primarily by individual caudate neurons, and the different reward information was represented in caudate subpopulations with distinct electrophysiological properties, e. g., baseline firing and spike width. These results suggest parallel processing of different reward information by the basal ganglia subdivisions defined by extrinsic connections and intrinsic properties.