Volume reduction of ventromedial prefrontal cortex in bipolar II patients with rapid cycling: A voxel-based morphometric study
Volume reduction of ventromedial prefrontal cortex in bipolar II patients with rapid cycling: A voxel-based morphometric study
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DOI：
10.1016/j.pnpbp.2010.11.030
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发表时间：
2011-03
影响因子：
5.6
通讯作者：
K. Narita;M. Suda;Y. Takei;Y. Aoyama;T. Majima;M. Kameyama;H. Kosaka;M. Amanuma;M. Fukuda;M. Mikuni
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文献类型：
--
作者：
K. Narita;M. Suda;Y. Takei;Y. Aoyama;T. Majima;M. Kameyama;H. Kosaka;M. Amanuma;M. Fukuda;M. Mikuni
尽管快速循环(RC)是双相I或II障碍的一种病程标志，与双相I患者相比，双相II患者尤其常见，但关于双相II合并RC的病理生理学证据仍然有限。在这项横断面设计的初步研究中，我们采用全脑和感兴趣区(ROI)分析方法，结合基于体素的形态计量学方法，检测了14例双相II型RC患者、17例非RC患者和84名健康对照的局部灰质(GM)体积。本研究中的全脑分析显示，与健康对照组相比，双相II型RC患者双侧眼眶内侧前额叶皮质、腹内侧前额叶皮质、扣带回前部、脑岛和海马旁，左侧颞叶下部皮质和小脑，以及脑干的GM体积减小。此外，ROI分析集中在腹侧前额叶皮质，即Brodmann区10，11和47，显示双相II伴RC的患者与无RC的患者相比，双相II的前额叶皮质Gm体积减小。我们的初步研究结果表明，在双相II型障碍中，腹内侧额叶皮质与RC的产生有关。
Although rapid cycling (RC), a course specifier of bipolar I or II disorder, is particularly common among bipolar II patients compared with bipolar I patients, the pathophysiological lines of evidence regarding bipolar II with RC are still limited. In this preliminary study with a cross-sectional design, we examined the regional gray matter (GM) volume in 14 bipolar II patients with RC, 17 patients without RC and 84 healthy controls by whole-brain and region-of-interest (ROI) analysis methods, using magnetic resonance imaging with voxel-based morphometry. Whole-brain analysis in this study revealed that the bipolar II patients with RC showed GM volume reductions in the bilateral hemispheres of the medial orbital prefrontal cortex, ventromedial prefrontal cortex, anterior cingulate, insula and parahippocampus, in the left hemisphere of the inferior temporal cortex and cerebellum, and in the brainstem, compared with the healthy controls. Moreover, ROI analysis focusing on the ventral prefrontal cortex, i.e., Brodmann areas 10, 11 and 47, revealed that the bipolar II patients with RC showed GM volume reduction in the ventromedial prefrontal cortex, compared with the patients without RC. The findings of our pilot study suggest that the ventromedial prefrontal cortex is associated with the generation of RC in bipolar II disorder.