BIOMICROSCOPIC AND HISTOPATHOLOGIC CONSIDERATIONS REGARDING THE FEASIBILITY OF SURGICAL EXCISION OF SUBFOVEAL NEOVASCULAR MEMBRANES
BIOMICROSCOPIC AND HISTOPATHOLOGIC CONSIDERATIONS REGARDING THE FEASIBILITY OF SURGICAL EXCISION OF SUBFOVEAL NEOVASCULAR MEMBRANES
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DOI：
10.1016/s0002-9394(14)72951-4
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发表时间：
1994-09-15
影响因子：
4.2
通讯作者：
GASS, JDM
中科院分区：
文献类型：
--
作者：
GASS, JDM
手术切除黄斑中心凹下新生血管膜可能使假定的眼组织胞浆菌病患者恢复极好的视力，但对年龄相关性黄斑变性患者则不然。为了解释这种差异，我分析了5例假定为眼部组织胞浆菌病的患者的临床和组织病理学结果。这些发现提供了证据表明，这些患者脉络膜中产生的新血管通常生长在视网膜感觉下空间内，而不是像年龄相关性黄斑变性患者那样生长在色素上皮下空间内。在假定的眼组织胞浆菌病中，新生血管部分被单层增生的视网膜色素上皮细胞吞噬。手术切除这层膜可以使视网膜感受器和天然色素上皮重新接近，并可能与视力的显著恢复有关。
Surgical excision of subfoveal neovascular membranes may result in recovery of excellent visual acuity in patients with presumed ocular histoplasmosis but not in patients with age-related macular degeneration. To provide an explanation for this discrepancy, I analyzed the clinical and histopathologic findings in five patients with presumed ocular histoplasmosis. These findings provide evidence that the new vessels arising in the choroid in these patients usually grow within the subsensory retinal space and not in the subpigment epithelial space, as occurs in patients with age-related macular degeneration. In presumed ocular histoplasmosis, the new vessels are partly engulfed by a monolayer of proliferating retinal pigment epithelium. Surgical excision of this membrane permits reapproximation of the retinal receptors and native pigment epithelium and may be associated with remarkable return of visual acuity.