STABILITY STUDIES IN RELATION TO IR DATA OF SOME SCHIFF-BASE COMPLEXES OF TRANSITION-METALS AND THEIR BIOLOGICAL AND PHARMACOLOGICAL STUDIES
STABILITY STUDIES IN RELATION TO IR DATA OF SOME SCHIFF-BASE COMPLEXES OF TRANSITION-METALS AND THEIR BIOLOGICAL AND PHARMACOLOGICAL STUDIES
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DOI：
10.1016/s0020-1693(00)83468-4
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发表时间：
1988-03-01
期刊：
影响因子：
--
通讯作者：
MOHAN, G
中科院分区：
文献类型：
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作者：
PARASHAR, RK;SHARMA, RC;MOHAN, G
合成了水杨醛缩2-取代苯胺Schiff碱及其Cu（II）、Ni（II）、Co（II）配合物，并通过元素分析、热重分析、红外光谱、电子光谱、摩尔电导和磁化率等方法进行了表征。用红外光谱法研究了Cu（Ⅱ）、Ni（Ⅱ）、Co（Ⅱ）与Schiff碱的成键方式。参与配位的基团的能带位置的移动已被用来估计金属-氮键长。所得结果与金属-氮模和配位场分裂能（10 Dq）值符合得很好。合成的配体及其金属配合物对革兰氏阳性菌（金黄色葡萄球菌）、革兰氏阴性菌（大肠杆菌）和真菌如尼日尔曲霉、构巢曲霉和白色念珠菌（Candida albicans）的抗菌活性已被测定，与单独的配体分子相比，有机配体的抗菌活性增加数倍。然而，它们的抗炎活性表现出不同的模式，一些配体的活性超过其各自的金属螯合物。值得注意的是，只有钴配合物表现出抗炎活性。
Schiff bases derived from salicylaldehyde and 2-substituted anilines and their Cu(II), Ni(II) and Co(II) complexes have been synthesized and characterized by their elemental analysis, TGA, IR and electronic spectral studies, molar conductance and magnetic susceptibility measurements. The mode of bonding between Cu(II), Ni(II) and Co(Il) and Schiff bases has been studied by IR spectrophotometry. The shift in the band positions of the groups involved in coordination has been utilized to estimate the metal- nitrogen bond lengths. The results obtained are in good agreement with the values of metal-nitrogen modes and ligand-field splitting energy (10Dq). The antimicrobial activities of the synthesized ligands and their metal complexes have been determined on Gram-positive (Staphylococcus aureus), Gram- negative (Escherichia coli) bacteria and on fungi likeAspergillus niger,Aspergillus nidulenseandCandida albicans.The antimicrobial activity of the organic ligands increased several folds on chelation as compared to the ligand molecule alone. However, their anti-inflammatory activity showed a different pattern; the activity of some ligands was more than their respective metal chelates. It is interesting to note that only cobalt complexes exhibited anti-inflammatory activity.