A benchtop system to assess cortical neural interface micromechanics
A benchtop system to assess cortical neural interface micromechanics
复制标题
DOI：
10.1109/tbme.2007.897139
复制
发表时间：
2007-06-01
影响因子：
4.6
通讯作者：
Rousche, P. J.
中科院分区：
文献类型：
--
作者：
Das, R.;Gandhi, D.;Rousche, P. J.
开发了一种台式脑组织微电极插入模型系统，以帮助改进皮质神经界面的设计。该模型通过使用人类尸体大脑标本（n（标本）= 6）或暴露于生理相关机械振荡的琼脂凝胶部分模拟体内环境。150 μ m直径的不锈钢微电极丝（TS = 600 MPa）植入3.0 cm固定人初级听觉皮层（n（试验）bbb10），承受峰值和稳定轴向力分别为133 +/- 8和64 +/- 4 mN。当受到3hz， 3mm垂直振荡时，测得148 +/- 10 mN的动态力幅值（n(trial) bbb10）。该模型系统允许研究和比较静力和动力及其对植入微电极结构的机械影响。
A benchtop brain tissue-microelectrode insertion model system was developed to aid in improving the design of cortical neural interfaces. The model partially mimics the in vivo environment via the use of human cadaver brain specimens (n(specimen) = 6), or agar gel exposed to physiologically relevant mechanical oscillations. 150 mu m diameter stainless-steel microelectrode wires (TS = 600 MPa) implanted 3.0 cm within fixed human primary auditory cortex (n(trial) > 10) experienced 133 +/- 8 and 64 +/- 4 mN of peak and steady axial forces. When subjected to a 3 Hz, 3-mm vertical oscillation, dynamic force amplitudes (n(trial) > 10) of 148 +/- 10 mN were measured. The model system allows the study and comparison of static and dynamic forces and their mechanical influences on proposed implanted microelectrode structures.