Serum organochlorine pesticides and PCBs and breast cancer risk: results from a prospective analysis (USA)
Serum organochlorine pesticides and PCBs and breast cancer risk: results from a prospective analysis (USA)
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DOI：
10.1023/a:1008824131727
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发表时间：
1999-02-01
影响因子：
2.3
通讯作者：
Taylor, PR
中科院分区：
文献类型：
--
作者：
Dorgan, JF;Brock, JW;Taylor, PR
目的：为了前瞻性地评估有机氯农药和多氯联苯（PCBs）与乳腺癌的关系，我们进行了一项病例对照研究嵌套在一个队列中使用的哥伦比亚，密苏里州乳腺癌血清Bank.Methods：妇女献血在1977-87年，并在长达9.5年的随访，105捐助者谁符合纳入标准，目前的研究被诊断为乳腺癌。对于每个病例，选择两个年龄和采血日期匹配的对照。五滴滴涕[2，2-双（对氯苯基）-1，1，1-三氯乙烷]类似物，13个其他有机氯农药，和27多氯联苯在serum.Results：妇女在上三个四分位数的六氯苯的两倍，乳腺癌的风险相比，在最低的四分位数。然而，没有证据表明存在剂量-反应关系，并且这种关联仅限于在接近诊断时采集血液的女性。妇女血清中其他有机氯农药和多氯联苯水平较高，总体上没有增加乳腺癌的风险，虽然积极的协会建议PCB-118和PCB-138时，育雏收集接近的时间diagnosis.Conclusions：本研究的结果不支持有机氯农药和多氯联苯在乳腺癌病因的作用。
Objective: To prospectively evaluate relationships of organochlorine pesticides and polychlorinated biphenyls (PCBs) with breast cancer, we conducted a case-control study nested in a cohort using the Columbia, Missouri Breast Cancer Serum Bank.Methods: Women donated blood in 1977-87, and during up to 9.5 years follow-up, 105 donors who met the inclusion criteria for the current study were diagnosed with breast cancer. For each case, two controls matched on age and date of blood collection were selected. Five DDT [2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane] analogs, 13 other organochlorine pesticides, and 27 PCBs were measured in serum.Results: Women in the upper three quartiles of hexachlorobenzene were at twice the risk of breast cancer compared to those in the lowest quartile. However, there was no evidence for a dose-response relationship, and the association was limited to women whose blood was collected close to the time of diagnosis. Women with higher serum levels of other organochlorine pesticides and PCBs showed no increased risk of breast cancer overall, although positive associations were suggested for PCB-118 and PCB-138 when brood was collected close to the time of diagnosis.Conclusions: Results of this study do not support a role for organochlorine pesticides and PCBs in breast cancer etiology.