IMMUNOCYTOCHEMICAL LOCALIZATION, IN SYNAPSES, OF PROTEIN-I, AN ENDOGENOUS SUBSTRATE FOR PROTEIN-KINASES IN MAMMALIAN BRAIN
IMMUNOCYTOCHEMICAL LOCALIZATION, IN SYNAPSES, OF PROTEIN-I, AN ENDOGENOUS SUBSTRATE FOR PROTEIN-KINASES IN MAMMALIAN BRAIN
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DOI：
10.1073/pnas.76.11.5982
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发表时间：
1979-01-01
影响因子：
11.1
通讯作者：
GREENGARD, P
中科院分区：
文献类型：
--
作者：
BLOOM, FE;UEDA, T;GREENGARD, P
Protein I, purified from bovine brain, is a principal endogenous substrate for cyclic AMP- and Ca2+-dependent protein kinases of mammalian brain. Antibodies raised against purified protein I were used to localize this protein in the rat CNS system. At the light microscope level, immunoreactivity was detected in punctate deposits in selected zones of synaptic termination. These deposits varied in density among brain regions. At the EM level, immunoreactivity was observed at some but not all synaptic regions and was restricted to the perimeter of synaptic vesicles and to submembranous material in the postsynaptic neuron.
