Long-Term Management of Incidental Bladder Cancer Detected in Patients Undergoing Prostatectomy for Prostate Cancer.
Long-Term Management of Incidental Bladder Cancer Detected in Patients Undergoing Prostatectomy for Prostate Cancer.
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因前列腺癌接受前列腺切除术的患者中发现的偶发性膀胱癌的长期治疗。
DOI：
10.1159/000499278
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Ogura Y.
中科院分区：
文献类型：
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作者：
Soga N;Furusawa J;Ogura Y.
在我们的机构，筛查偶发性膀胱癌是常规进行，以避免肿瘤细胞扩散所造成的手术切除前列腺癌（PCa）的患者。在这里，我们报告的长期临床结果，在患者的偶发性膀胱癌检测到的常规筛查前percutaneous.Materials和MethodsBetween 2003年1月至2013年12月，430例患者接受percutaneous切除术切除PCa被纳入本队列研究。所有患者均接受膀胱镜检查、尿沉渣分析和尿细胞学检查以检测偶发性膀胱癌。结果膀胱偶发癌的发生率为2.1%（9/430）。所有肿瘤均为位于尿道口周围或外侧的单一乳头状肿瘤，诊断为尿路上皮癌（UC）。尿沉渣分析或尿细胞学检查未发现显著结果。经尿道切除的病理结果显示5例pTa伴1级UC，4例pTa伴2级UC。9例患者中有8例接受了雄激素剥夺治疗。在观察期间（平均7.2年），2例患者（2年和7.3年）发现UC复发。然而，经尿道切除术成功地完全切除了肿瘤。在平均19.6个月（12-25个月）无UC复发后，7例患者（77.8%）接受了直肠切除术，2例患者接受了放疗或雄激素剥夺治疗。前列腺切除术进行无传播UC在observationperiod. ConclusionIncidentalUC中检测到2.1%的前列腺切除术候选人。术前常规膀胱镜检查有助于发现早期偶发UC。
IntroductionAt our institution, screening for incidental bladder cancer is routinely performed to avoid tumor cell dissemination caused by surgery in patients undergoing prostatectomy for prostate cancer (PCa). Here, we report the long-term clinical results in patients with incidental bladder cancer detected by routine screening prior to prostatectomy.Materials and MethodsBetween January 2003 and December 2013, 430 patients undergoing prostatectomy for resection of PCa were enrolled in this cohort study. All patients underwent screening with cystoscopy, urinary sediment analysis, and urinary cytology to detect incidental bladder cancer. The clinical outcomes of cases with incidental bladder cancer were evaluated.ResultsThe incidence of incidental bladder cancer was 2.1%(9/430). All tumors were single papillary tumors located around the urinary orifice or lateral side and were diagnosed as urothelial cancer (UC). No significant findings were detected by urinary sediment analysis or urinary cytology. Pathological results of transurethral resections revealed 5 cases of pTa with Grade 1 UC and 4 cases of pTa with Grade 2 UC. Androgen-deprivation therapy was administered to 8/9 patients. During the observation period (average of 7.2 years), UC recurrence was detected in 2 cases (2 and 7.3 years). However, transurethral resection successfully removed the tumor completely. After an average of 19.6 months (12-25 months) without UC recurrence, 7 patients (77.8%) underwent prostatectomy, and 2 patients received radiation or androgen-deprivation therapy. Prostatectomy was carried out without dissemination of UC during the observation period.ConclusionIncidental UC was detected in 2.1% of prostatectomy candidates. Preoperative routine screening with flexible cystoscopy was useful to detect early incidental UC.