Increased plasma levels of cytokines after seizures in localization-related epilepsy
Increased plasma levels of cytokines after seizures in localization-related epilepsy
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DOI：
10.1111/j.1600-0404.2007.00882.x
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发表时间：
2007-10-01
影响因子：
3.5
通讯作者：
Peltola, J.
中科院分区：
文献类型：
--
作者：
Lehtimaki, K. A.;Keranen, T.;Peltola, J.
目的：实验研究表明，长时间癫痫发作后，大脑产生的炎性细胞因子增加。人类患者单一的非延长发作是否与细胞因子网络的激活有关尚不清楚。材料与方法：对慢性局限性癫痫患者单次发作后进行脑电视频记录，检测其血浆中白介素1β(IL-1β)、白介素1受体拮抗剂(IL-1ra)、白介素6(IL-6)及可溶性IL-6受体(sIL-6R和gp130)的水平。结果癫痫发作后IL-1ra和IL-6水平升高，而IL-1β和IL-6受体无明显变化。结论--这些结果表明，只有单次癫痫发作才能激活细胞因子级联反应和相关的炎症信号。在反复发作的情况下，这些信号可能会导致神经组织的结构变化，这通常与药物难治性癫痫有关。
Objectives - Experimental studies suggest increased cerebral production of inflammatory cytokines after prolonged seizures. Whether a single non-prolonged seizure in human patients is associated with activation of cytokine network is still unknown. Materials and methods - We studied the levels of interleukin-1 beta (IL-1 beta), interleukin-1 receptor antagonist (IL-1ra), interlukin-6 (IL-6) and soluble IL-6 receptors (sIL-6R and Gp130) in plasma after single seizures during video-EEG recordings in patients with chronic localization-related epilepsy. Results - The levels of IL-1ra and IL-6 were increased after seizures, whereas IL-1 beta and IL-6 cytokine receptors remained unchanged. Conclusions - These results show that only single seizures cause activation of cytokine cascade and associated inflammatory signals. In the case of recurrent seizures, these signals may result in structural changes in the nervous tissue, which are generally associated with drug refractory epilepsy.