Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat
Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat
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DOI：
10.1210/jc.2014-3678
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发表时间：
2015-06-01
影响因子：
5.8
通讯作者：
Mulligan, Kathleen
中科院分区：
文献类型：
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作者：
Schwarz, Jean-Marc;Noworolski, Susan M.;Mulligan, Kathleen
研究背景：高果糖饮食可促进肝脏脂肪酸合成（从头脂肪生成[DNL]）和致动脉粥样硬化脂质谱。目前还不清楚这些影响是否独立于正能量平衡和体重增加而发生。目的：我们比较了高果糖，（25%的能量含量）维持体重的饮食与具有相同的常量营养素分布但其中复合碳水化合物（CCHO）取代果糖的等热量饮食的那些。设计、设置和参与者：8名健康男性作为住院患者进行了连续9天的研究。稳定同位素示踪剂用于测量肝DNL分数和内源性葡萄糖产生（EGP）及其在正常血糖-高胰岛素钳夹过程中的抑制。结果：体重保持稳定。无论饮食的喂养顺序如何，高果糖饮食与所有参与者的DNL（平均值为18.6 +/- 1.4%，CCHO为11.0 +/- 1.4%; P = 0.001）和肝脏脂肪（中位数为CCHO的+137%; P = 0.016）均相关。空腹EGP和胰岛素介导的葡萄糖处置没有显著差异，但高胰岛素血症期间EGP更大（0.60 +/- 0.07 vs 0.46 +/- 0.06 mg/kg/min; P = 0.013），提示EGP.Conclusion：短期高果糖摄入与维持体重饮食的健康男性DNL和肝脏脂肪增加相关。
Context: Consumption of high-fructose diets promotes hepatic fatty acid synthesis (de novo lipogenesis [DNL]) and an atherogenic lipid profile. It is unclear whether these effects occur independent of positive energy balance and weight gain.Objectives: We compared the effects of a high-fructose, (25% of energy content) weight-maintaining diet to those of an isocaloric diet with the same macronutrient distribution but in which complex carbohydrate (CCHO) was substituted for fructose.Design, Setting, and Participants: Eight healthy men were studied as inpatients for consecutive 9-day periods. Stable isotope tracers were used to measure fractional hepatic DNL and endogenous glucose production (EGP) and its suppression during a euglycemic-hyperinsulinemic clamp. Liver fat was measured by magnetic resonance spectroscopy.Results: Weight remained stable. Regardless of the order in which the diets were fed, the high-fructose diet was associated with both higher DNL (average, 18.6 +/- 1.4% vs 11.0 +/- 1.4% for CCHO; P = .001) and higher liver fat (median, + 137% of CCHO; P = .016) in all participants. Fasting EGP and insulin-mediated glucose disposal did not differ significantly, but EGP during hyperinsulinemia was greater (0.60 +/- 0.07 vs 0.46 +/- 0.06 mg/kg/min; P = .013) with the high-fructose diet, suggesting blunted suppression of EGP.Conclusion: Short-term high-fructose intake was associated with increased DNL and liver fat in healthy men fed weight-maintaining diets.