Synthesis of 1(2H)-isoquinolones by the nickel-catalyzed denitrogenative alkyne insertion of 1,2,3-benzotriazin-4(3H)-ones
Synthesis of 1(2H)-isoquinolones by the nickel-catalyzed denitrogenative alkyne insertion of 1,2,3-benzotriazin-4(3H)-ones
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DOI：
10.1021/ol8010826
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发表时间：
2008-07-17
期刊：
影响因子：
5.2
通讯作者：
Murakami, Masahiro
中科院分区：
文献类型：
--
作者：
Miura, Tomoya;Yamauchi, Motoshi;Murakami, Masahiro
1，2，3-苯并三嗪-4（3（H）-酮在镍（0）/膦催化剂作用下，与内炔和末端炔反应，高产率地合成了一系列取代的1（2 H）-异喹诺酮。反应通过三嗪酮部分的脱氮活化和随后的炔插入进行。
1,2,3-Benzotriazin-4(3(H)-ones reacted with internal and terminal alkynes in the presence of a nickel(0)/phosphine catalyst to give a wide range of substituted 1(2H)-isoquinolones in high yield. The reaction proceeded through denitrogenative activation of the triazinone moiety and the following insertion of alkynes.