Cytokine decoy and scavenger receptors as key regulators of immunity and inflammation.
Cytokine decoy and scavenger receptors as key regulators of immunity and inflammation.
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DOI：
10.1016/j.cyto.2016.06.023
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发表时间：
2016-11
期刊：
影响因子：
3.8
通讯作者：
Riva F
中科院分区：
文献类型：
--
作者：
Bonecchi R;Garlanda C;Mantovani A;Riva F
IL-1 R2是第一个被描述的诱饵受体。随后，已经描述了细胞因子和趋化因子的受体，其充当纯诱饵或清除剂或触发细胞因子信号传导的抑制。在这里，我们回顾了目前的理解的作用方式和意义的病理学的趋化因子非典型受体ACKR 2，IL-1诱饵受体IL-1 R2和非典型IL-1受体家族IL-1 R8。没有或非典型信号传导的诱饵和清道夫受体已经作为在进化中保守的调节细胞因子、趋化因子和生长因子的作用的一般策略而出现。
IL-1R2 was the first decoy receptor to be described. Subsequently receptors which act as pure decoys or scavengers or trigger dampening of cytokine signaling have been described for cytokines and chemokines. Here we review the current understanding of the mode of action and significance in pathology of the chemokine atypical receptor ACKR2, the IL-1 decoy receptor IL-1R2 and the atypical IL-1 receptor family IL-1R8. Decoy and scavenger receptors with no or atypical signaling have emerged as a general strategy conserved in evolution to tune the action of cytokines, chemokines and growth factors.