National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee.
National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee.
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DOI：
10.1016/j.bbmt.2010.12.713
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发表时间：
2011-04
影响因子：
4.3
通讯作者：
Giralt, Sergio
中科院分区：
文献类型：
--
作者：
Bishop, Michael R.;Alyea, Edwin P., III;Cairo, Mitchell S.;Falkenburg, J. H. Frederik;June, Carl H.;Kroeger, Nicolaus;Little, Richard F.;Miller, Jeffrey S.;Pavletic, Steven Z.;Porter, David L.;Riddell, Stanley R.;van Besien, Koen;Wayne, Alan S.;Weisdorf, Daniel J.;Wu, Roy S.;Giralt, Sergio
第一届异基因造血干细胞移植后复发的生物学、预防和治疗国际研讨会的组织和召开旨在确定、优先考虑和协调未来与异基因造血干细胞移植（alloHSCT）后复发相关的研究活动。讲习班的六个工作委员会都发表了关于正在进行的基础研究、转化研究和临床研究的个别报告，并建议了与复发生物学、流行病学、预防和治疗有关的未来研究领域。本文件总结了每个委员会的建议，并提出了三个主要倡议，以协调研究工作，以解决alloHSCT后复发的问题。首先是需要建立多中心相关和临床试验网络，用于基础/转化、流行病学和临床研究。其次，需要一个生物储存库网络，用于在alloHSCT前后收集样本，以帮助实验室和临床研究。第三，应进一步完善、实施和研究研讨会提出的疾病特异性反应和复发定义以及监测微小残留病的建议。这些建议与正在进行的研究计划和移植组织协调，提供了一个研究框架，以快速有效地解决alloHSCT后复发的重大问题。
The First International Workshop on The Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation was organized and convened to identify, prioritize, and coordinate future research activities related to relapse after allogeneic hematopoietic stem cell transplantation (alloHSCT). Each of the Workshop’s six working committees have published individual reports of ongoing basic, translational and clinical research and recommended areas for future research related to the areas of relapse biology, epidemiology, prevention and treatment. This document summarizes each of the committees’ recommendations and suggests three major initiatives for a coordinated research effort to address the problem of relapse after alloHSCT. The first is the need to establish multi-center correlative and clinical trials networks for basic/translational, epidemiological, and clinical research. Second, there is a need for a network of biorepositories for the collection of samples pre- and post-alloHSCT to aid in laboratory and clinical studies. Third, there should be further refinement, implementation, and study of the proposed Workshop disease-specific response and relapse definitions and the recommendations for monitoring of minimal residual disease. These recommendations, in coordination with ongoing research initiatives and transplant organizations, provide a research framework to rapidly and efficiently address the significant problem of relapse following alloHSCT.
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影响因子：
45.3
作者：
Bader, P;Kreyenberg, H;Klingebiel, T
通讯作者：
Klingebiel, T
DOI：
10.1016/j.bbmt.2010.06.008
发表时间：
2010-09
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Kröger N;Bacher U;Bader P;Böttcher S;Borowitz MJ;Dreger P;Khouri I;Macapinlac HA;Olavarria E;Radich J;Stock W;Vose JM;Weisdorf D;Willasch A;Giralt S;Bishop MR;Wayne AS
通讯作者：
Wayne AS
影响因子：
4.3
作者：
Alyea, Edwin P.;DeAngelo, Daniel J.;Moldrem, Jeffrey;Pagel, John M.;Przepiorka, Donna;Sadelin, Michel;Young, James W.;Giralt, Sergio;Bishop, Michael;Riddell, Stan
通讯作者：
Riddell, Stan
影响因子：
20.3
作者：
Bellucci, R;Alyea, EP;Ritz, J
通讯作者：
Ritz, J
影响因子：
20.3
作者：
Meunier, MC;Roy-Proulx, G;Perreault, C
通讯作者：
Perreault, C