Myriads: P-value-based multiple testing correction
Myriads: P-value-based multiple testing correction
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DOI：
10.1093/bioinformatics/btx746
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发表时间：
2018-03-15
期刊：
影响因子：
5.8
通讯作者：
Carvajal-Rodriguez, Antonio
中科院分区：
文献类型：
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作者：
Carvajal-Rodriguez, Antonio
动机：有许多多种测试纠正方法。其中一些对数据中的各种依赖项具有鲁棒性，而另一些则没有。目前，微阵列和其他基因组技术要求管理高维p值列表，其中一些实现存在问题。结果：程序Myriads（以前称为sof +）提供了一些最重要的基于p值的校正方法，以及依赖性测试和p值模拟器。Myriads可以轻松管理数十万个p值。
Motivation: There are many multiple testing correction methods. Some of them are robust to various dependencies in the data while others are not. Some of the implementations have problems for managing high dimensional list of P-values as currently demanded by microarray and other omic technologies.Results: The program Myriads, formerly SGoF+, provides some of the most important P-value-based correction methods jointly with a test of dependency and a P-value simulator. Myriads easily manage hundreds of thousands of P-values.