Antidepressant- and anxiolytic effects of the novel melatonin agonist Neu-P11 in rodent models
Antidepressant- and anxiolytic effects of the novel melatonin agonist Neu-P11 in rodent models
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DOI：
10.1038/aps.2010.80
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发表时间：
2010-06
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影响因子：
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通讯作者：
S. Tian;M. Laudon;Li-xiu Han;Jun Gao;F. Huang;Yufeng Yang;Haifeng Deng
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作者：
S. Tian;M. Laudon;Li-xiu Han;Jun Gao;F. Huang;Yufeng Yang;Haifeng Deng
目的：探讨新型褪黑激素激动剂new - p11对两种大鼠抑郁模型和小鼠焦虑模型的潜在抗抑郁和抗焦虑作用。方法：在学习无助试验（LH）中，大鼠在黑暗期开始前2 h给药new - p11或褪黑素（25-100 mg/kg, ip），每天1次，连续5 d，记录试验期逃避失败次数和试验间交叉次数。在强迫游泳试验（FST）中，大鼠接受单次或重复给药（25-100 mg/kg, ip）。评估试验阶段的总静止时间。在升高+迷宫试验（EPM）中，小鼠在早上或晚上分别给予new - p11 （25-100 mg/kg, ip）或褪黑激素，并在2小时后进行测试。评估了在张开双臂和张开双臂的入口中花费的时间百分比。结果：在LH试验中，Neu-P11显著降低了逃避赤字，而褪黑素没有显著降低，对试验间交叉没有影响。在FST中，无论是在早上还是晚上，单次或重复给药nue - p11，都能显著减少不活动的持续时间。在EPM测试中，与给药时间无关，new - p11显著增加了在张开手臂和张开手臂条目中花费的时间百分比。褪黑素只有在下午服用时才有效。结论：nue - p11在啮齿动物模型中具有抗抑郁和抗焦虑活性。类似的内容被其他人浏览
Aim:To investigate the potential antidepressant and anxiolytic effects of Neu-P11, a novel melatonin agonist, in two models of depression in rats and a model of anxiety in mice.Methods:In the learned helplessness test (LH), Neu-P11 or melatonin (25–100 mg/kg, ip) was administered to rats 2 h before the beginning of the dark phase once a day for 5 days and the number of escape failures and intertrial crossings during the test phase were recorded. In the forced swimming test (FST), rats received a single or repeated administration of Neu-P11 (25–100 mg/kg, ip). The total period of immobility during the test phase was assessed. In the elevated plus-maze test (EPM), mice were treated with Neu-P11 (25–100 mg/kg, ip) or melatonin in the morning or in the evening and tested 2 h later. The percentage of time spent in the open arms and the open arms entries were assessed.Results:In the LH test, Neu-P11 but not melatonin significantly decreased the escape deficit and had no effect on the intertrial crossings. In the FST, a single or repeated administration of Neu-P11, either in the morning or in the evening, significantly decreased the duration of immobility. In the EPM test, Neu-P11 significantly increased the percentage of time spent in the open arms and the open arms entries irrespective to the time of administration. Melatonin was effective only when administered in the afternoon.Conclusion:The results demonstrate that Neu-P11 exerts antidepressant and anxiolytic activities in rodent models.Similar content being viewed by others