RARE SEQUENCE MOTIFS ARE COMMON CONSTITUENTS OF HYPERVARIABLE ANTIBODY REGIONS
RARE SEQUENCE MOTIFS ARE COMMON CONSTITUENTS OF HYPERVARIABLE ANTIBODY REGIONS
复制标题
DOI：
10.1016/s0769-2625(87)80023-5
复制
发表时间：
1987-09-01
期刊：
影响因子：
--
通讯作者：
KOURILSKY, P
中科院分区：
文献类型：
--
作者：
CHALUFOUR, A;BOUGUELERET, L;KOURILSKY, P
对人和小鼠抗体分子可变区域的氨基酸序列进行了分析。它包括将它们的组成四肽与在参考集（体细胞自我）中发现的四肽进行比较，这些参考集是用蛋白质数据库中发现的非免疫蛋白质构建的。高变区，特别是CDR1和CDR3，通常由参考集中不存在的稀有四肽组成。通过简单的统计检验，这种偏倚是显著的。我们讨论了它与抗体免疫原性问题的可能联系。这一结果为“肽自我模型”预测的二肽的存在提供了间接支持。
An analysis of the amino acid sequences of variable regions of human and mouse antibody molecules was performed. It involved comparison of their constituent tetrapeptides with those found in a reference set (the somatic self) built with non-immunological proteins found in a protein data base. It appeared that hypervariable regions, particularly CDR1 and CDR3, are often made up of rare tetrapeptides not present in the reference set. As assessed by simple statistical tests, this bias was significant. We discuss its possible connection with the problem of antibody immunogenicity. This result provides indirect support for the existence of idiopeptides predicted by the "peptidic self model".