Review on material parameters to enhance bone cell function in vitro and in vivo.
Review on material parameters to enhance bone cell function in vitro and in vivo.
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DOI：
10.1042/bst20200210
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发表时间：
2020-10-30
影响因子：
3.9
通讯作者：
Kohn DH
中科院分区：
文献类型：
--
作者：
Madsen E;Mededovic M;Kohn DH
骨骼在支撑、保护、运动和新陈代谢方面起着关键作用。尽管骨骼具有天生的再生能力，但这种能力是有限的，许多骨骼损伤和疾病都需要干预。生物材料是许多恢复骨骼功能的治疗方法的关键组成部分，包括用于增强骨骼的不可吸收植入物和用于引导再生的可吸收材料。生物材料在生物相容性和生物活性方面可能有很大差异，这是特定材料参数的函数。生物材料在骨增强和再生方面的成功取决于它们对骨细胞功能的影响。这些功能包括黏附、迁移、炎症、增殖、通讯、分化、吸收和血管形成。这篇综述将重点关注不同的材料参数如何在体外和体内增强骨细胞功能。
Bone plays critical roles in support, protection, movement, and metabolism. Although bone has an innate capacity for regeneration, this capacity is limited, and many bone injuries and diseases require intervention. Biomaterials are a critical component of many treatments to restore bone function and include non-resorbable implants to augment bone and resorbable materials to guide regeneration. Biomaterials can vary considerably in their biocompatibility and bioactivity, which are functions of specific material parameters. The success of biomaterials in bone augmentation and regeneration is based on their effects on the function of bone cells. Such functions include adhesion, migration, inflammation, proliferation, communication, differentiation, resorption, and vascularization. This review will focus on how different material parameters can enhance bone cell function both in vitro and in vivo.