Adropin and apelin‐12 efficiently predict metabolic syndrome in obese children
Adropin and apelin‐12 efficiently predict metabolic syndrome in obese children
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Adropin 和 apelin™12 可有效预测肥胖儿童的代谢综合征
DOI：
10.1111/pedi.13101
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发表时间：
2020
影响因子：
3.4
通讯作者：
Meizheng Zhang
中科院分区：
文献类型：
--
作者：
Chunyan Yin;Hongai Zhang;Yanfeng Xiao;Meizheng Zhang
摘要：目的：代谢综合征（MetS）是与儿童和青少年肥胖相关的最常见疾病，也是一个具有挑战性的公共卫生问题。很少有研究描述 adropin 和 apelin-12 血清水平作为 MetS 预测因子的特异性和敏感性。本研究的目的是评估 adropin 和 apelin-12 的血清水平与 MetS 之间的关联，以及它们作为肥胖儿童 MetS 预测因子的敏感性……方法。本研究涉及 138 名儿童。研究组包括患有 MetS 的肥胖受试者，两个对照组包括没有 MetS 的肥胖受试者和正常体重受试者。收集人体测量参数和临床数据。还测量了 apelin-12、adropin、瘦素、脂联素和 TNF-α 的血浆水平...结果。与没有 MetS 的儿童相比，患有 MetS 的肥胖儿童的 apelin-12 水平显着较高，而 adropin 水平显着较低。在逻辑回归中，我们在调整年龄、性别和青春期后确定 apelin-12 是代谢综合征的危险因素，而 adropin 是代谢综合征的保护因素。此外，ROC 分析显示，adropin 和 apelin-12 是比瘦素和脂联素更敏感的代谢综合征预测因子...结论。血清 adropin 和 apelin-12 水平可以作为预测肥胖儿童 MetS 的有用生物标志物。我们的研究结果可以为治疗和预防 MetS 提供一种新方法。
Abstract.Objective.Metabolic syndrome (MetS) is the most common condition associated with childhood and adolescent obesity and is a challenging public health issue. Very few studies have described the specificity and sensitivity of serum levels of adropin and apelin-12 as predictors of MetS. The aim of this study was to evaluate the association between serum levels of adropin and apelin-12 and MetS, and their sensitivity as predictors of MetS in obese children...Methods.This study involved 138 children. The study group included obese subjects with MetS, and the two control groups included obese subjects without MetS and normal weight subjects. Anthropometric parameters and clinical data were collected. Plasma levels of apelin-12, adropin, leptin, adiponectin, and TNF-α were also measured...Results.Obese children with MetS had significantly higher levels of apelin-12 and significantly lower levels of adropin when compared with those in children without MetS. In logistic regressions, we identified that apelin-12 was a risk factor for metabolic syndrome, and adropin was a protecting factor of having MetS after adjusting for age, sex, and puberty. Furthermore, ROC analysis revealed that adropin and apelin-12 are more sensitive predictors of metabolic syndrome than leptin and adiponectin...Conclusion.Serum adropin and apelin-12 levels can be useful biomarkers for predicting MetS in obese children. Our findings could provide a novel approach for the treatment and prevention of MetS.