Early childhood family instability and immune system dysregulation in adolescence.
Early childhood family instability and immune system dysregulation in adolescence.
复制标题
幼儿期家庭不稳定和青春期免疫系统失调。
DOI：
10.1016/j.psyneuen.2018.12.014
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发表时间：
2019
影响因子：
3.7
通讯作者：
Browning,ChristopherR
中科院分区：
文献类型：
--
作者：
Schmeer,KammiK;Ford,JodiL;Browning,ChristopherR
儿童时期的社会不利条件可能会改变生物和心理系统，造成长期后果，而压力是其中一种方式。家庭的社会和经济条件对幼儿的发展至关重要，家庭条件困难可能会产生持久的生理影响。然而，很少有研究将儿童早期状况与青春期压力和系统失调的生理指标联系起来。在这项研究中，我们评估了儿童早期（出生至5岁）发生的家庭社会和经济不稳定性如何与青春期免疫系统失调相关，如EB病毒（EBV）的DNA脱落所示。我们利用通过唾液获得的EBV生物标志物，这是一种收集免疫系统生物标志物的非侵入性方法，在674名11-17岁的青少年中。多变量回归结果表明，在儿童早期搬进新的父母/照顾者家庭或与祖父母同住的经历与先前感染EBV的青少年中EBV DNA脱落估计增加100%相关。其他衡量幼儿家庭不稳定、家庭结构变化和经济不安全的指标都不太重要。同期的家庭条件与青少年的EBV DNA脱落无关。
Exposure to stress is one way in which social disadvantages during childhood may alter biological and psychological systems with long-term consequences. Family social and economic conditions are critical for early childhood development and exposure to difficult family conditions may have lasting physiological effects. However, there is little research linking early childhood conditions with physiological indicators of stress and system dysregulation in adolescence. In this study, we assess how family social and economic instability that occurred in early childhood (birth to age 5) is associated with immune system dysregulation in adolescence, as indicated by DNA shedding of the Epstein-Barr virus (EBV). We utilize a biomarker of EBV obtained through saliva, a non-invasive method of collecting immune-system biomarkers, in 674 adolescents 11–17 years old. Multivariable regression results indicated that experiences of moving into a new parent/caregiver household or moving in with a grandparent during early childhood was associated with an estimated 100% increase in EBV DNA shedding among prior EBV-infected adolescents. Other measures of early childhood family instability, total number of family structure changes and economic insecurity, were marginally significant. Contemporaneous family conditions were not associated with adolescents’ EBV DNA shedding.