Linoleic acid salt with ultrapure soft water as an antibacterial combination against dermato-pathogenic Staphylococcus spp.
Linoleic acid salt with ultrapure soft water as an antibacterial combination against dermato-pathogenic Staphylococcus spp.
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DOI：
10.1111/jam.13012
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发表时间：
2016-02-01
影响因子：
4
通讯作者：
Tanaka, A.
中科院分区：
文献类型：
--
作者：
Jang, H.;Makita, Y.;Tanaka, A.
目的葡萄球菌属的皮肤定植。严重影响人类和动物皮炎的严重程度。我们研究了不同类型的脂肪酸盐对葡萄球菌的抗菌活性。超纯水（UPSW）我们还评估了他们的治疗效果的自发犬模型dermatis.Methods和ResultsUPSW，其中Ca ++和Mg ++被替换为Na+，产生使用水软化剂与阳离子交换树脂。金黄色葡萄球菌（Staphylococcus aureus）、中间葡萄球菌（Staphylococcus intermedius）（Staphylococcus.中间葡萄球菌（Staphylococcus pseudintermedius）和假中间葡萄球菌（Staphylococcus pseudintermedius）与各种脂肪酸盐在蒸馏水（DW）或UPSW中孵育，并对细菌的数量进行计数。在脂肪酸中，油酸盐和亚油酸（LA）盐减少了这些细菌的数量。此外，UPSW还增强了LA对葡萄球菌的抗菌作用。spp.在同伴的狗自发性瘙痒性皮炎，洗发水治疗含有10%的LA在UPSWimproved skin conditions.ConclusionsLA盐对葡萄球菌表现出抗菌活性的液体肥皂。spp.用含有LA的肥皂和UPSW治疗可减少皮炎犬的临床症状。spp.在皮肤上使用含有LA的肥皂会加剧皮炎，在UPSW中使用含有LA的肥皂可以减少皮肤的不愉快的临床症状。
AimsSkin colonization of Staphylococcus spp. critically affects the severity of dermatitis in humans and animals. We examined different types of fatty acid salts for their antibacterial activity against Staphylococcus spp. when used in ultrapure soft water (UPSW). We also evaluated their therapeutic effect on a spontaneous canine model of dermatitis.Methods and ResultsUPSW, in which Ca++ and Mg++ were replaced with Na+, was generated using a water softener with cation-exchange resin. Staphylococcus aureus (Staph.aureus), Staphylococcus intermedius (Staph. intermedius), and Staphylococcus pseudintermedius (Staph.pseudintermedius) were incubated with various fatty acid salts in distilled water (DW) or UPSW and the number of bacteria was counted. Among the fatty acids, oleic acid salt and linoleic acid (LA) salt reduced the number of these bacteria. Also, UPSW enhanced the antibacterial effect of LA on Staph. spp. In spontaneously developed itchy dermatitis in companion dogs, shampoo treatment with liquid soap containing 10% LA in UPSW improved skin conditions.ConclusionsLA salt showed antibacterial activity against Staph. spp. Treatment with soap containing LA with UPSW reduced clinical conditions in dogs with dermatitis.Significance and Impact of the StudyBecause colonization of Staph. spp. on the skin exacerbates dermatitis, the use of LA-containing soap in UPSW may reduce unpleasant clinical symptoms of the skin.