VCP and PSMF1: Antagonistic regulators of proteasome activity
VCP and PSMF1: Antagonistic regulators of proteasome activity
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DOI：
10.1016/j.bbrc.2015.06.086
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发表时间：
2015-08-07
影响因子：
3.1
通讯作者：
Schroeder, Rolf
中科院分区：
文献类型：
--
作者：
Clemen, Christoph S.;Marko, Marija;Schroeder, Rolf
蛋白酶体的蛋白质周转和质量控制对于细胞稳态至关重要。蛋白酶体的功能障碍与衰老过程和人类疾病（例如神经退行性变、心肌病和癌症）有关。这种极其重要的蛋白质降解系统的调节（即激活和抑制）仍未得到广泛探索。我们在此证明，进化上高度保守的 II 型三 A ATP 酶 VCP 和蛋白酶体抑制剂 PSMF1/PI31 直接相互作用，并拮抗地调节蛋白酶体活性。我们的数据为蛋白酶体活性的调节提供了新的见解。 (C) 2015 年作者。由 Elsevier Inc. 出版。这是一篇遵循 CC BY-NC-ND 许可证 (http://creativecommons.org/licenses/hy-nc-nd/4.0/) 的开放获取文章。
Protein turnover and quality control by the proteasome is of paramount importance for cell homeostasis. Dysfunction of the proteasome is associated with aging processes and human diseases such as neurodegeneration, cardiomyopathy, and cancer. The regulation, i.e. activation and inhibition of this fundamentally important protein degradation system, is still widely unexplored. We demonstrate here that the evolutionarily highly conserved type II triple-A ATPase VCP and the proteasome inhibitor PSMF1/PI31 interact directly, and antagonistically regulate proteasomal activity. Our data provide novel insights into the regulation of proteasomal activity. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/hy-nc-nd/4.0/).