An unusual presentation of placental malaria: a single persisting nidus of sequestered parasites
An unusual presentation of placental malaria: a single persisting nidus of sequestered parasites
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DOI：
10.1016/j.humpath.2006.09.016
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发表时间：
2007-03-01
期刊：
影响因子：
3.3
通讯作者：
Duffy, Patrick E.
中科院分区：
文献类型：
--
作者：
Muehlenbachs, Atis;Mutabingwa, Theonest K.;Duffy, Patrick E.
由恶性疟原虫引起的胎盘疟疾是热带国家的一个公共卫生问题。用于检测胎盘疟疾的外周血涂片通常为阴性，并且在怀孕期间复发是常见的。我们在恶性疟原虫流行地区对一系列首次分娩的母亲进行胎盘组织学检查。在一个没有其他外周或胎盘血寄生虫病证据的妇女的单个绒毛间隙中，通过胎盘组织学鉴定出单个疟疾感染红细胞的病灶。这一发现表明环期感染的红细胞在体内被隔离，或者恶性疟原虫可以作为休眠的血期形式持续存在。(c) 2007年Elsevier Inc.出版
Placental malaria caused by Plasmodium falciparum is a public health concern in tropical countries. Peripheral blood smears to detect placental malaria are often negative, and recrudescences are common during pregnancy. We performed placental histology on a series of first-time mothers delivering in an area endemic for P falciparum. A single nidus of malaria-infected erythrocytes was identified by placental histology in a single intervillous space from a woman who had no other evidence of peripheral or placental blood parasitemia. This finding suggests ring stage-infected erythrocytes sequester in vivo, or P falciparum can persist as a dormant blood stage form. (c) 2007 Published by Elsevier Inc.