Features of anosmia in COVID-19
Features of anosmia in COVID-19
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DOI：
10.1016/j.medmal.2020.04.006
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发表时间：
2020-08-01
影响因子：
5
通讯作者：
Zayet, S.
中科院分区：
文献类型：
--
作者：
Klopfenstein, T.;Kadiane-Oussou, N. J.;Zayet, S.
背景。-关于COVID-19嗅觉缺失的医学出版物很少。我们的目的是描述COVID-19患者嗅觉缺失的患病率和特征。我们回顾性地纳入了2020年3月1日至3月17日期间出现嗅觉缺失的COVID-19患者。采用SARS-CoV-2实时聚合酶链反应（real - time PCR）对呼吸道样本进行检测。114例确诊COVID-19患者中有54例（47%）报告嗅觉缺失。54例患者平均年龄47（±16）岁；67%为女性，37%住院治疗。Charlson共病指数中位数为0.70（+/- 1.6[0-7]）。46例患者（85%）有读写困难，28%出现肺炎。感染后4.4（+/- 1.9[1-8]）天开始出现嗅觉缺失。嗅觉缺失的平均持续时间为8.9（+/- 6.3[1-21]）天，98%的患者在28天内恢复。在我们的欧洲COVID-19患者中，有一半存在嗅觉缺失，并且通常与记忆障碍有关。(C) 2020 Elsevier Masson SAS。版权所有。
Background. - Medical publications about anosmia with COVID-19 are scarce. We aimed to describe the prevalence and features of anosmia in COVID-19 patients.Methods. - We retrospectively included COVID-19 patients with anosmia between March 1st and March 17th, 2020. We used SARS-CoV-2 real time PCR in respiratory samples to confirm the cases.Results. - Fifty-four of 114 patients (47%) with confirmed COVID-19 reported anosmia. Mean age of the 54 patients was 47 (+/- 16) years; 67% were females and 37% were hospitalised. The median Charlson comorbidity index was 0.70 (+/- 1.6 [0-7]). Forty-six patients (85%) had dysgeusia and 28% presented with pneumonia. Anosmia began 4.4 (+/- 1.9 [1-8]) days after infection onset. The mean duration of anosmia was 8.9 (+/- 6.3 [1-21]) days and 98% of patients recovered within 28 days.Conclusions. - Anosmia was present in half of our European COVID-19 patients and was often associated with dysgeusia. (C) 2020 Elsevier Masson SAS. All rights reserved.