Body composition of children with cancer
Body composition of children with cancer
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DOI：
10.3945/ajcn.2010.29201
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发表时间：
2010-07-01
影响因子：
7.1
通讯作者：
Davies, Peter S. W.
中科院分区：
文献类型：
--
作者：
Murphy, Alexia J.;White, Melinda;Davies, Peter S. W.
背景资料：以身体成分为代表的营养状况是儿科癌症患者治疗中的一个重要考虑因素，因为它与不良结局有关。儿童的身体成分对癌症和治疗的反应知之甚少。目的：我们旨在比较接受癌症治疗的儿童与健康对照儿童的身体成分，并比较血液恶性肿瘤儿童和实体瘤儿童的身体成分。设计：这项横断面研究测量了48名接受癌症和血液相关疾病治疗的儿童和年龄匹配的健康对照组的身高、体重、体细胞质量、去脂肪质量和脂肪质量。与对照组相比，癌症患者的体细胞质量指数z评分（女性体细胞质量/身高的幂为2.5，男性为3）显著降低（P = 0.0001），根据体细胞质量，45%的癌症患者被认为营养不良。与对照组相比，癌症受试者的体脂百分比（P = 0.0001）和脂肪质量（P = 0.0001）显著较高;然而，无脂肪质量无显著差异（P = 0.09）。根据脂肪百分比，77%的癌症患者被认为是肥胖的。癌症types.Conclusions：这项研究表明，接受治疗的所有类型的癌症的儿童有一个显着较低的体细胞质量和显着较高的脂肪量比健康对照组之间的身体组成没有显着差异。建议所有接受癌症治疗的儿童给予营养支持。美国临床营养杂志2010; 92：55-60。
Background: Nutritional status, as represented by body composition, is an important consideration in the treatment of pediatric cancer patients because it is linked to poor outcomes. Little is known about how a child's body composition responds to cancer and treatment.Objectives: We aimed to compare the body composition of children undergoing treatment of cancer with that of healthy controls and to compare body composition between children with hematologic malignancies and children with solid tumors.Design: This cross-sectional study measured height, weight, body cell mass, fat-free mass, and fat mass in 48 children undergoing treatment of cancer and blood-related disorders and in age-matched healthy controls.Results: Patients with cancer had a significantly lower body cell mass index z score (body cell mass/height raised to the power of 2.5 for females and 3 for males) than did controls (P = 0.0001), and 45% of the patients with cancer were considered malnourished according to body cell mass. Subjects with cancer had a significantly higher percentage of body fat (P = 0.0001) and fat mass (P = 0.0001) than did controls; however, there was no significant difference in fat-free mass (P = 0.09). On the basis of percentage fat, 77% of subjects with cancer were considered obese. No difference in body composition was observed between cancer types.Conclusions: This study showed that children undergoing treatment of all types of cancer have a significantly lower body cell mass and a significantly higher fat mass than do healthy controls. Nutritional support is suggested for all children undergoing treatment of cancer. Am J Clin Nutr 2010; 92: 55-60.