The role of protective HCPS and HLA-C associated polymorphisms in the control of HIV-1 replication in a subset of elite suppressors
The role of protective HCPS and HLA-C associated polymorphisms in the control of HIV-1 replication in a subset of elite suppressors
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DOI：
10.1097/qad.0b013e3282f470e4
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发表时间：
2008-02-19
期刊：
影响因子：
3.8
通讯作者：
Blankson, Joel N.
中科院分区：
文献类型：
--
作者：
Han, Yefei;Lai, Jun;Blankson, Joel N.
我们的研究结果表明，NVP/EFV相关孤立性皮疹的机制与肝脏/全身反应病例的机制不同。孤立的皮疹风险似乎仅取决于易感等位基因HLA-DRB 1 *01的存在，而肝脏/全身反应的风险与遗传和免疫因素之间的相互作用有关。需要在更大的队列中进一步研究NVP/EFV相关反应（例如肝毒性、发热和/或皮疹）的特征。新的研究应该能够确定潜在的风险因素。这将导致诊断测试的发展，并有助于减少或消除NVP/EFV过敏反应的发生率。
The results of our study suggest that the mechanism of NVP/EFV-related isolated rash is different from the mechanism in cases with hepatic/systemic reactions. The isolated rash risk appears to depend on the presence of the predisposing allele HLA-DRB1*01 alone, whereas the risk of hepatic/systemic reactions is associated with an interaction between genetic and immunological factors. Further studies characterizing the NVP/EFV-associated reactions (e.g. hepatotoxicity, fever and/or rash) with larger cohorts are needed. New studies should allow the identification of the underlying risk factors. This would lead to the development of a diagnostic test, and help decrease or eliminate the incidence of NVP/EFV hypersensitive reactions.