A new nano-cryosurgical modality for tumor treatment using biodegradable MgO nanoparticles
A new nano-cryosurgical modality for tumor treatment using biodegradable MgO nanoparticles
复制标题
使用可生物降解的氧化镁纳米粒子治疗肿瘤的新纳米冷冻手术方式
DOI：
10.1016/j.nano.2012.02.010
复制
发表时间：
2012-11-01
影响因子：
5.4
通讯作者：
Liu, Jing
中科院分区：
文献类型：
--
作者：
Di, De-Rui;He, Zhi-Zhu;Liu, Jing
本文提出了一种纳米冷冻肿瘤消融的新概念模式。主要策略是应用无毒、可生物降解且对人体副作用小的氧化镁纳米颗粒（NPs）来有效介导冷冻过程。通过动物实验和成核分析进行的详细研究表明，将 MgO NP 递送到目标组织中将显着改善冷冻手术的结果。由于氧化镁纳米颗粒优异的热性能，冷冻过程中冰球的形成加速并扩大。此外，该方法还可以促进冰核的产生，从而增强对靶细胞的冷冻损伤。因此，将氧化镁纳米颗粒的生物降解性和无毒性与其相对轻质的特性和优异的热性能相结合将有助于开发高性能的冷冻手术。这些发现可能会带来安全、有针对性的纳米冷冻手术的方法，并可能突破当前癌症临床治疗面临的障碍。
A new conceptual modality for nano-cryosurgical ablation of tumors is proposed in this article. The main strategy is to apply MgO nanoparticles (NPs), which are nontoxic, biodegradable, and have few side-effects on the human body, to mediate the freezing procedure effectively. Detailed investigation via animal experiments and nucleation analysis demonstrated that delivery of MgO NPs into the target tissues would significantly improve the cryosurgical outcome. The formation of an iceball during the freezing process is accelerated and enlarged due to the excellent thermal properties of MgO NPs. In addition this method could promote the generation of ice nuclei and thus enhance cryoinjury to the target cells. Therefore, combining the biodegradability and nontoxicity of MgO NPs with their relatively lightweight properties, excellent thermal properties would help develop a high-performance cryosurgery. These findings may lead to methods for safe and targeted nano-cryosurgery and possibly break through the barriers facing current clinical treatments of cancer.