Articular Cartilage Calcification of the Humeral Head Is Highly Prevalent and Associated With Osteoarthritis in the General Population
Articular Cartilage Calcification of the Humeral Head Is Highly Prevalent and Associated With Osteoarthritis in the General Population
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DOI：
10.1002/jor.23227
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发表时间：
2016-11-01
影响因子：
2.8
通讯作者：
Niemeier, Andreas
中科院分区：
文献类型：
--
作者：
Hawellek, Thelonius;Hubert, Jan;Niemeier, Andreas
关节软骨钙化被认为是一种病理性的，尽管尚未完全了解的过程，已知与膝关节和髋关节的骨关节炎相关。本研究的目的是确定肩关节作为非承重关节的关节软骨钙化的患病率，并分析钙化与年龄和肩关节骨关节炎组织学严重程度的相互关系。在一项对90名供体（n = 49名男性，n = 41名女性;平均年龄62.7岁[20-93]）的180个肱骨头进行的横断面研究中，通过数字接触式X线摄影（DCR）对肱骨头的软骨钙化进行定量。测定骨关节炎组织学分级（OARSI），并采用结构方程模型（SEM）分析软骨钙化、OARSI与年龄的相互关系。关节软骨钙化的患病率为98.9%（95%CI：[93.96%，99.97%]），与性别无关（p = 0.55）。一侧肩关节钙化与对侧肩关节钙化显著相关（r = 0.61，95%CI：[0.46，0.73]，p
Articular cartilage calcification is considered a pathological albeit incompletely understood process which is known to be associated with osteoarthritis of the knee and hip. The goal of this study was to determine the prevalence of articular cartilage calcification of the shoulder as a non-weight-bearing joint and to analyze the interrelationship of calcification with age and histological severity of shoulder osteoarthritis in the general population. In a cross-sectional study of 180 humeral heads from 90 donors (n = 49 male, n = 41 female; mean age 62.7 years [20-93]), cartilage calcification of the humeral head was quantified by digital contact radiography (DCR). Histological OA grade (OARSI) was determined and structural equation modeling (SEM) was used to analyze the interrelationship of cartilage calcification, OARSI and age. The prevalence of articular cartilage calcification was 98.9% (95%CI: [93.96%, 99.97%]) and was independent of gender (p = 0.55). Cartilage calcification of one shoulder correlated significantly with that of the contralateral side (r = 0.61, 95% CI: [0.46, 0.73], p