Magnetic nanoparticles encapsulated into biodegradable microparticles steered with an upgraded magnetic resonance imaging system for tumor chemoembolization
Magnetic nanoparticles encapsulated into biodegradable microparticles steered with an upgraded magnetic resonance imaging system for tumor chemoembolization
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DOI：
10.1016/j.biomaterials.2009.08.005
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发表时间：
2009-11-01
期刊：
影响因子：
14
通讯作者：
Martel, Sylvain
中科院分区：
文献类型：
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作者：
Pouponneau, Pierre;Leroux, Jean-Christophe;Martel, Sylvain
在这项工作中，治疗磁性微载体（TMMC）引导在真实的时间的磁共振成像（MRI）系统提出作为一种手段，以改善药物输送到肿瘤部位。考虑到MRI导向约束和肝肿瘤化疗栓塞的生理参数，设计了磁性铁钴纳米颗粒，其封装在具有适当饱和磁化强度（M-s）的可生物降解聚（D，L-乳酸-羟基乙酸）（PLGA）微粒中。FeCo纳米粒子的粒径为182 nm，M-s为209 emu g（-1）。它们涂覆有多层石墨壳以使封装步骤期间M-s的减少最小化。FeCo-PLGA微粒的平均直径为58 μ m，M-s为61 emu g（-1），在模拟肝动脉及其分叉的模型中进行操纵，其流量与肝动脉流量的数量级相同。转向效率，定义为靶向分叉通道中FeCo-PLGA微粒的量除以注射的FeCo-PLGA微粒的总量，达到86%。本文提出的数据证实了这些TMMC的转向的可行性。(C)2009爱思唯尔有限公司保留所有权利。
In this work, therapeutic magnetic micro carriers (TMMC) guided in real time by a magnetic resonance imaging (MRI) system are proposed as a mean to improve drug delivery to tumor sites. MRI steering constraints and physiological parameters for the chemoembolization of liver tumors were taken into account to design magnetic iron-cobalt nanoparticles encapsulated into biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) microparticles with the appropriate saturation magnetization (M-s). FeCo nanoparticles displayed a diameter of 182nm and an M-s of 209 emu g(-1). They were coated with a multilayered graphite shell to minimize the reduction of M-s during the encapsulation steps. FeCo-PLGA microparticles, with a mean diameter of 58 mu m and an M-s of 61 emu g(-1), were steered in a phantom mimicking the hepatic artery and its bifurcation, with a flow in the same order of magnitude as that of the hepatic artery flow. The steering efficiency, defined as the amount of FeCo-PLGA microparticles in the targeted bifurcation channel divided by the total amount of FeCo-PLGA microparticles injected, reached 86%. The data presented in this paper confirms the feasibility of the steering of these TMMC. (C) 2009 Elsevier Ltd. All rights reserved.