Response to "cortico-accumbens circuitry in schizophrenia: merely a reward system?" by Rolland and Jardri (SCHRES-14-D-00731).
Response to "cortico-accumbens circuitry in schizophrenia: merely a reward system?" by Rolland and Jardri (SCHRES-14-D-00731).
复制标题
对“精神分裂症中的伏隔皮质回路：仅仅是一个奖励系统？”的回应
DOI：
10.1016/j.schres.2014.10.008
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发表时间：
2015
影响因子：
4.5
通讯作者：
Green,AlanI
中科院分区：
文献类型：
--
作者：
Fischer,AdinaS;Whitfield-Gabrieli,Susan;Roth,RobertM;Brunette,MaryF;Green,AlanI
We appreciate the interest of Rolland and Jardri in our paper (Fischer et al., 2014). The authors suggest that the circuitry we observed to be abnormal in patients with schizophrenia and cannabis use disorder, that we and others have noted to be involved in reward processing (Blum et al., 2000; Di Martino et al., 2008; Green, 2007) has also been implicated in “other functional (eg, salience processing) and dysfunctional (eg, psychosis)” processes. We agree, and as we noted in our paper, that the use of resting state functional connectivity “does not directly measure response to reward, and the brain regions implicated in the brain reward circuit are also involved in processes other than reward.” Potentially, future research correlating resting state functional connectivity of the implicated circuitry with analyses of task-based data would be helpful, although others have noted correspondence between resting state networks and task-based findings (Di Martino et al., 2008; Fox and Greicius, 2010; Whitfield-Gabrieli and Ford, 2011)In their recent publication, Rolland and colleagues (Rolland et al., 2014) linked hallucinations in patients with schizophrenia to connectivity between the nucleus accumbens (NAc), ventral tegmental area (VTA), and a number of other regions generally consistent with what we referred to as the brain reward circuit. Moreover, they noted in their letter that
