Cingulo-opercular network activity maintains alertness
Cingulo-opercular network activity maintains alertness
复制标题
DOI：
10.1016/j.neuroimage.2016.01.026
复制
发表时间：
2016-03-01
期刊：
影响因子：
5.7
通讯作者：
Kleinschmidt, Andreas
中科院分区：
文献类型：
--
作者：
Coste, Clio P.;Kleinschmidt, Andreas
先前对警觉性的研究将其与选择性注意混淆，因为目标是高度可预测的。为了真正隔离警觉性，我们设计了一个稀疏的事件相关设计，其中有许多不同的随机出现和交错的听觉和视觉目标，从而使预测效率低下。使用功能性磁共振成像，我们然后分析了局部大脑活动变化的影响之前，任务的外观上的反应时间，从而避免信号的贡献刺激驱动的注意力。扣带-鳃盖网络和默认模式网络中较高的前刺激活性导致较快的反应速度，但只有前者表现出任务积极反应。相反，背侧注意网络刺激前活动是整体无关的，听觉试验，甚至不利于性能。因此，在一个范例中，没有信息预测的时间，模态或属性的后续刺激，我们的研究结果解离警觉性，无论是解剖学和功能，从注意力和建立的核心作用的扣带-鳃盖神经网络维持警觉性。(C)2016 Elsevier Inc. All rights reserved.
Previous investigations of alertness have confounded it with selective attention because targets were highly predictable. To truly isolate alertness we devised a sparse event-related design with many different randomly appearing and interleaved auditory and visual targets, thereby rendering prediction inefficient. Using functional magnetic resonance imaging, we then analyzed the influence of local brain activity variations prior to task appearance on reaction times, thus avoiding signal contributions from stimulus-driven attention. Higher prestimulus activity in a cingulo-opercular network, and the default mode network, resulted in faster response speed but only the former network showed task-positive responses. Conversely, dorsal attention network prestimulus activity was overall irrelevant and on auditory trials even detrimental to performance. Thus, in a paradigm where no information predicted timing, modality or properties of a subsequent stimulus, our results dissociate alertness, both anatomically and functionally, from attention and establish the central role of the cingulo-opercular network for sustaining alertness. (C) 2016 Elsevier Inc. All rights reserved.