Interleukin-1β in synovial fluid from the arthritic temporomandibular joint and ets relation to pain, mobility, and anterior open bite
Interleukin-1β in synovial fluid from the arthritic temporomandibular joint and ets relation to pain, mobility, and anterior open bite
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DOI：
10.1016/s0278-2391(98)90256-7
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发表时间：
1998-09-01
影响因子：
1.9
通讯作者：
Kopp, S
中科院分区：
文献类型：
--
作者：
Alstergren, P;Ernberg, M;Kopp, S
目的：本研究的目的是调查是否白细胞介素-1 β在滑液或血浆参与疼痛或痛觉过敏的颞下颌关节（TMJ）的发展，以及减少下颌骨的流动性和前开bite.Patients和方法：29例TMJ关节炎和7名健康受试者进行了研究。评估颞下颌关节触诊疼痛（TDP）、颞下颌关节压力疼痛阈值和耐受水平（PPTL）、下颌活动度、关节运动时疼痛和前牙开咬程度（AOB）的VAS测量。分析TMJ滑液中IL-1 β水平结果：SF-IL-1 β与VAS疼痛评分、TDP、AOB呈显著正相关，与PPTL呈显著负相关。这项研究表明，IL-IP在滑液中与疼痛和痛觉过敏的颞下颌关节区域以及前开咬。关于后一种情况，IL-IP似乎是组织破坏的警告信号。
Purpose: The purpose of this study was to investigate whether interleukin-1 beta in synovial fluid or blood plasma is involved in the development of pain or hyperalgesia of the temporomandibular joint (TMJ), as well as reduced mandibular mobility and anterior open bite.Patients and Methods: Twenty-nine patients with TMJ arthritis and seven healthy subjects were studied. VAS measurement of TMJ tenderness on palpation of the TMJ (TDP), TMJ pressure pain threshold and tolerance level (PPTL), mandibular mobility, pain during joint movements, and degree of anterior open bite (AOB) were assessed. IL-1 beta levels were analyzed in TMJ synovial fluid (SF-IL-1 beta) and blood samples and correlated with the preceding factors.Results: SF-IL-1 beta showed significant positive correlations with VAS measurement of pain, TDP, and AOB and a negative correlation with PPTL.Conclusions: This study indicates that IL-IP in the synovial fluid is associated with pain and hyperalgesia in the TMJ region as well as an anterior open bite. Concerning the latter condition, IL-IP seems to be a warning signal of tissue destruction.