Spontaneous regression of advanced cancer: Identification of a unique genetically determined, age-dependent trait in mice
Spontaneous regression of advanced cancer: Identification of a unique genetically determined, age-dependent trait in mice
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DOI：
10.1073/pnas.1031601100
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发表时间：
2003-05-27
影响因子：
11.1
通讯作者：
DeLong, CJ
中科院分区：
文献类型：
--
作者：
Cui, Z;Willingham, MC;DeLong, CJ
我们已经建立并研究了一个小鼠群体，该群体具有对可移植细胞诱导的腹水和实体癌的独特宿主抗性。这种特性的一个显著表现是晚期癌症的年龄依赖性自发消退。这种强大的抗性作为单基因座显性性状分离，不依赖于肿瘤负荷，并且对多种类型癌症的细胞系有效。在自发消退期间或暴露后立即，癌细胞引起宿主白细胞的大量浸润，其与肿瘤细胞形成聚集体并融合。先天性白细胞对癌细胞的溶细胞破坏是快速和特异的，对正常细胞没有明显的损伤。这些小鼠是健康的，没有癌症，寿命正常。这些观察结果提示了一种以前未被认识到的免疫监视机制。其可能具有治疗或预防癌症的潜力。
We have established and studied a colony of mice with a unique trait of host resistance to both ascites and solid cancers induced by transplantable cells. One dramatic manifestation of this trait is age-dependent spontaneous regression of advanced cancers. This powerful resistance segregates as a single-locus dominant trait, is independent of tumor burden, and is effective against cell lines from multiple types of cancer. During spontaneous regression or immediately after exposure, cancer cells provoke a massive infiltration of host leukocytes, which form aggregates and rosettes with tumor cells. The cytolytic destruction of cancer cells by innate leukocytes is rapid and specific without apparent damage to normal cells. The mice are healthy and cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance,. which may have potential for therapy or prevention of cancer.