Epidemiology of penicillinase-producing Neisseria gonorrhoeae infections: analysis by auxotyping and serogrouping.

Epidemiology of penicillinase-producing Neisseria gonorrhoeae infections: analysis by auxotyping and serogrouping.
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产生青霉素酶的淋病奈瑟菌感染的流行病学:通过基因型和血清分型进行分析。

DOI:
10.1056/nejm198204223061602
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发表时间:
1982
期刊:
The New England journal of medicine
影响因子:
--
通讯作者:
Holmes,KK
Holmes,KK
中科院分区:
--
文献类型:
--
作者:
Handsfield,HH;Sandstrom,EG;Knapp,JS;Perine,PL;Whittington,WL;Sayers,DE;Holmes,KK

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采用辅助分型和凝集分型方法对华盛顿州、路易斯安那州什里夫波特和远东地区产青霉素酶淋病奈瑟菌和青霉素酶阴性菌株进行鉴定。来自华盛顿的75株产青霉素酶的菌株中有54株(72%)需要脯氨酸才能生长,并且是W-I群(Pro-I),这是菲律宾产青霉素酶的主要菌株类型;来自华盛顿的86株青霉素酶阴性菌株中没有一株是Pro-I(P<0.0001)。来自什里夫波特的38株青霉素酶产生菌全部需要脯氨酸,且均为W-II群(Pro-II);来自什里夫波特的26株青霉素酶阴性菌株中有5株(19%)也是Pro-II群(P<0.0001),但W-II群具有抗原特异性,使其有别于青霉素酶产生菌。我们得出的结论是,华盛顿和什里夫波特的疫情是由于进口菌株的传播,而不是青霉素酶编码质粒向本土淋球菌的传播。什里夫波特疫情涉及一株产青霉素酶的N。淋病可能起源于一个共同的源头,而华盛顿的多源疫情涉及几种类型,这表明反复引入新的毒株。(英国医学杂志)1982年;306:950-4。)
Auxotyping and serogrouping by coagglutination were used to characterize penicillinase-producingNeisseria gonorrhoeaeand penicillinase-negative isolates from the state of Washington, Shreveport (Louisiana), and the Far East. Fifty-four of 75 penicillinase-producing isolates (72 per cent) from Washington required proline for growth and were serogroup W-I (Pro-I), the predominant type of penicillinase-producing strains in the Philippines; none of 86 penicillinase-negative isolates from Washington was Pro-I (P<0.0001). All 38 penicillinase-producing isolates from Shreveport required proline and were serogroup W-II (Pro-II); five of 26 penicillinase-negative isolates (19 per cent) from Shreveport were also Pro-II (P<0.0001) but had antigenic specificities within serogroup W-II that distinguished them from the penicillinase-producing isolates. We conclude that the Washington and Shreveport outbreaks resulted from the spread of imported strains rather than transmission of penicillinase-encoding plasmids to indigenous gonococci. The Shreveport outbreak involved a single strain of penicillinase-producingN. gonorrhoeaeand probably originated from a common source, whereas several types were involved in the multiple-source Washington outbreak, indicating repeated introduction of new strains. (N Engl J Med. 1982; 306:950–4.)
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发表时间: 1981
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