The activity of Nef on HIV-1 infectivity.
The activity of Nef on HIV-1 infectivity.
复制标题
DOI：
10.3389/fmicb.2014.00232
复制
发表时间：
2014
影响因子：
5.2
通讯作者：
Pizzato M
中科院分区：
文献类型：
--
作者：
Basmaciogullari S;Pizzato M
慢病毒的复制和致病性受到除典型逆转录病毒 ORF gag、pol 和 env 之外表达的“辅助蛋白”的关键调节。人们经常寻求并提出抑制此类蛋白质活性的策略，作为可能的补充，以提高传统抗逆转录病毒疗法的功效。这需要深入了解其功能背后的分子机制。 Nef辅助蛋白由灵长类慢病毒独特表达，在病毒体内复制和艾滋病发病中发挥重要作用。 Nef 的多种活性之一是通过一种至今仍然神秘的机制增强子代病毒体的内在感染性。在这里，我们回顾了有关此类活动的当前知识，并讨论了其在艾滋病毒生物学中可能发挥的作用。
The replication and pathogenicity of lentiviruses is crucially modulated by “auxiliary proteins” which are expressed in addition to the canonical retroviral ORFs gag, pol, and env. Strategies to inhibit the activity of such proteins are often sought and proposed as possible additions to increase efficacy of the traditional antiretroviral therapy. This requires the acquisition of an in-depth knowledge of the molecular mechanisms underlying their function. The Nef auxiliary protein is expressed uniquely by primate lentiviruses and plays an important role in virus replication in vivo and in the onset of AIDS. Among its several activities Nef enhances the intrinsic infectivity of progeny virions through a mechanism which remains today enigmatic. Here we review the current knowledge surrounding such activity and we discuss its possible role in HIV biology.
登录
查看更多内容
影响因子：
5.7
作者：
Arold, S;Franken, P;Dumas, C
通讯作者：
Dumas, C
影响因子：
3.7
作者：
Cavrois, M;Neidleman, J;Greene, WC
通讯作者：
Greene, WC
影响因子：
5.4
作者：
AIKEN, C;TRONO, D
通讯作者：
TRONO, D
影响因子：
64.5
作者：
AIKEN, C;KONNER, J;TRONO, D
通讯作者：
TRONO, D
影响因子：
32.4
作者：
BAUR, AS;SAWAI, ET;PETERLIN, BM
通讯作者：
PETERLIN, BM