OLIGOSACCHARIDES - HOW CAN FLEXIBLE MOLECULES ACT AS SIGNALS
OLIGOSACCHARIDES - HOW CAN FLEXIBLE MOLECULES ACT AS SIGNALS
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DOI：
10.1351/pac199365040763
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发表时间：
1993-04-01
影响因子：
1.8
通讯作者：
CARVER, JP
中科院分区：
文献类型：
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作者：
CARVER, JP
有大量证据表明，大多数寡糖是柔性的，也就是说，它们以许多不同的构象存在。那么，它们如何有效地作为识别信号呢？必须有一种机制来降低这种灵活性，以便可以实现“识别”现象的高亲和力、高特异性、结合特性。在个别糖基化位点的分子相互作用的具体设置建议负责。通过这种特异性相互作用，给定寡糖的总群体的子集能够充当识别信号。由于在糖基化位点与蛋白质表面的相互作用起主导作用，我们称这种机制为“定点呈递”。前面描述的“现场定向处理”现象只是更一般的现场定向呈现现象的一个特例。这种现象的可能的分子模型进行了审查和实验基础。
There is considerable evidence that the majority of oligosaccharides are flexible, that is, they exist in many different conformations. How, then, can they act effectively as recognition signals? There must be a mechanism to reduce this flexibility so that the high-affinity, high-specificity, binding characteristic of ''recognition'' phenomena can be achieved. Specific sets of molecular interactions at individual glycosylation sites are suggested to be responsible. Through such specific interactions, subsets of the total population of a given oligosaccharide could be capable of acting as recognition signals. Since a dominant role is played by interactions with the protein surface at the glycosylation site, we term this mechanism ''site-directed presentation''. The previously described phenomenon of ''site-directed processing'' is simply a special case of the more general site-directed presentation phenomenon. Possible molecular models for this phenomenon are reviewed and the experimental bases presented.