Age-dependent measures of anxiety and cognition in male histidine decarboxylase knockout (Hdc-/-) mice
Age-dependent measures of anxiety and cognition in male histidine decarboxylase knockout (Hdc-/-) mice
复制标题
DOI：
10.1016/j.brainres.2005.11.067
复制
发表时间：
2006-02-03
期刊：
影响因子：
2.9
通讯作者：
Raber, J
中科院分区：
文献类型：
--
作者：
Acevedo, SF;Ohtsu, H;Raber, J
组氨酸脱羧酶缺陷（Hdc（-/-））和野生型雄性小鼠的C57 B16/J背景，用于确定组胺在脑功能中的作用。3-5（Y）和12-14（MA）月龄Hdc（-/-）小鼠在旷场、明暗、高架十字迷宫和高架零迷宫测试中表现出活动减退和焦虑程度增加。Y Hdc（-/-）小鼠在水迷宫的隐藏会话和被动回避记忆保持中表现出上级的表现。相比之下，Y Hdc（-/-）小鼠在新的位置识别受损，花费更少的时间在目标象限搜索和更多的时间在水迷宫的外区搜索在探测试验。这些行为可能是由于增加的焦虑措施，并没有发现在MA Hdc（-/-）小鼠。这些数据支持组胺在焦虑和认知中的作用，并强调了在解释组胺能神经传递在认知功能中的作用时考虑年龄和对焦虑措施的潜在影响的重要性。(C)2005 Elsevier B. V.保留所有权利。
Histidine decarboxylase deficient (Hdc(-/-)) and wild-type male mice on the C57B16/J background were used to determine the role of histamine in brain function. 3-5 (Y) and 12-14 (MA) month-old Hdc(-/-) mice showed hypoactivity and increased measures of anxiety in the open field, light-dark, elevated plus-maze, and elevated zero maze tests. Y Hdc(-/-) mice showed superior performance in the hidden sessions of the water maze and passive avoidance memory retention. In contrast, Y Hdc(-/-) mice were impaired in novel location recognition, spent less time searching in the target quadrant and more time searching in the outer zone of the water maze during the probe trials. These behaviors are likely due to increased measures of anxiety and are not found in MA Hdc(-/-) mice. These data support a role for histamine in anxiety and cognition and underline the importance of considering age and potential effects on measures of anxiety in the interpretation of the role of histaminergic neurotransmission in cognitive function. (C) 2005 Elsevier B.V. All rights reserved.