Evidence for Brain Activation in Patients With Takotsubo Cardiomyopathy
Evidence for Brain Activation in Patients With Takotsubo Cardiomyopathy
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DOI：
10.1253/circj.cj-13-1276
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发表时间：
2014-01-01
影响因子：
3.3
通讯作者：
Shimokawa, Hiroaki
中科院分区：
文献类型：
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作者：
Suzuki, Hideaki;Matsumoto, Yasuharu;Shimokawa, Hiroaki
背景：takotsubo心肌病患者脑活动是否发生改变仍有待阐明。方法与结果：连续3例takotsubo型心肌病患者，采用Tc-99m乙基半胱氨酸二聚体单光子发射计算机断层扫描（SPECT）检测急性期和慢性期脑血流量（CBF）。所有患者急性期海马、脑干和基底节区CBF均显著增加，前额叶皮质区CBF显著减少，慢性期随着心壁运动完全恢复，CBF变化逐渐减弱。结论：这些结果为takotsubo心肌病的脑激活提供了第一个直接证据。
Background: It remains to be elucidated whether brain activity is altered in takotsubo cardiomyopathy.Methods and Results: We measured cerebral blood flow (CBF) in 3 consecutive patients with takotsubo cardiomyopathy using Tc-99m ethyl cysteinate dimmer single photon-emission computed tomography (SPECT) in the acute and chronic phases. In all patients, CBF was significantly increased in the hippocampus, brainstem and basal ganglia and significantly decreased in the prefrontal cortex in the acute phase, which changes subsided in the chronic phase with full recovery of cardiac wall motion.Conclusions: These results provide the first direct evidence for brain activation in takotsubo cardiomyopathy.