Assessment of protein assembly prediction in CASP13
Assessment of protein assembly prediction in CASP13
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DOI：
10.1002/prot.25795
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发表时间：
2019-08-27
影响因子：
2.9
通讯作者：
Duarte, Jose M.
中科院分区：
文献类型：
--
作者：
Guzenko, Dmytro;Lafita, Aleix;Duarte, Jose M.
我们在CASP社区范围实验的第13版中提出了组装类别评估。第二次，蛋白质组装构成了一个独立的评估类别。与上一版相比，我们看到了参与的明确吸收，更多的寡聚目标被释放，以及预测质量的一致（尽管是适度的）改善。在三级结构预测中，我们观察到忽略目标的低聚状态会阻碍建模的成功。我们还注意到，一些接触预测组成功地预测了同质界面接触，尽管这些预测似乎没有用于组装建模。具有相当大的人为干预的同源建模似乎形成了这一轮CASP中组装预测技术的基础。未来的开发应该看到更多的集成方法，其中子单元在它们形成的程序集的上下文中建模。
We present the assembly category assessment in the 13th edition of the CASP community-wide experiment. For the second time, protein assemblies constitute an independent assessment category. Compared to the last edition we see a clear uptake in participation, more oligomeric targets released, and consistent, albeit modest, improvement of the predictions quality. Looking at the tertiary structure predictions, we observe that ignoring the oligomeric state of the targets hinders modeling success. We also note that some contact prediction groups successfully predicted homomeric interfacial contacts, though it appears that these predictions were not used for assembly modeling. Homology modeling with sizeable human intervention appears to form the basis of the assembly prediction techniques in this round of CASP. Future developments should see more integrated approaches where subunits are modeled in the context of the assemblies they form.