Inconsistencies in the assessment of food intake.
Inconsistencies in the assessment of food intake.
复制标题
食物摄入量评估不一致。
DOI：
10.1152/ajpendo.00415.2012
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Langhans,Wolfgang
中科院分区：
文献类型：
--
作者：
Woods,StephenC;Langhans,Wolfgang
许多影响新陈代谢的肽和其他化合物也会影响食物摄入，多年来人们提出了许多假设来解释观察到的能量稳态效应。例如，胆囊收缩素（CCK），一种在进餐时分泌的十二指肠肽，有助于消化，也会减少持续的食物摄入，从而有助于饱腹感;胰岛素和瘦素，与身体脂肪成正比分泌的激素，在大脑中起作用，通过减少能量摄入来帮助控制肥胖。这些行为动作通常被认为是硬连线的，使得阴性实验，其中施用的化合物不能具有其声称的效果，通常被忽略。事实上，无法复制化合物对食物摄入量的影响是司空见惯的，这种情况在实验室之间和实验室内部都有发生。复制失败在历史上引发了关于一种或另一种化合物的功效和/或正常功能的激烈争论，导致文献中的混乱和模糊。我们回顾这些现象及其影响，并认为，而不是引发硬连线的行为反应，在维持稳态，化合物，改变食物摄入量受到许多影响，可以使他们完全无效的时候，这种变化的一个主要原因是，食物摄入量是不是严格的稳态控制。
Many peptides and other compounds that influence metabolism also influence food intake, and numerous hypotheses explaining the observed effects in terms of energy homeostasis have been suggested over the years. For example, cholecystokinin (CCK), a duodenal peptide secreted during meals that aids in digestion, also reduces ongoing food intake, thereby contributing to satiation; and insulin and leptin, hormones secreted in direct proportion to body fat, act in the brain to help control adiposity by reducing energy intake. These behavioral actions are often considered to be hard-wired, such that negative experiments, in which an administered compound fails to have its purported effect, are generally disregarded. In point of fact, failures to replicate the effects of compounds on food intake are commonplace, and this occurs both between and within laboratories. Failures to replicate have historically fueled heated debate about the efficacy and/or normal function of one or another compound, leading to confusion and ambiguity in the literature. We review these phenomena and their implications and argue that, rather than eliciting hard-wired behavioral responses in the maintenance of homeostasis, compounds that alter food intake are subjected to numerous influences that can render them completely ineffective at times and that a major reason for this variance is that food intake is not under stringent homeostatic control.