Amyloid beta 1-42 deposits do not lead to Alzheimer's neuritic plaques in aged dogs.
Amyloid beta 1-42 deposits do not lead to Alzheimer's neuritic plaques in aged dogs.
复制标题
淀粉样蛋白 β 1-42 沉积物不会导致老年犬出现阿尔茨海默氏症神经炎斑块。
DOI：
10.1042/bj3130575
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Frangione,B
中科院分区：
文献类型：
--
作者：
Wisniewski,T;Lalowski,M;Bobik,M;Russell,M;Strosznajder,J;Frangione,B
In Alzheimer's disease, amyloid β (Aβ) is deposited in senile plaques and amyloid angiopathy. Longer Aβ peptides, which extend to residue 42 (Aβ42), have been suggested to be critical for the seeding of amyloid. Aged dogs develop cerebral vessel amyloid and parenchymal preamyloid lesions. Preamyloid in humans is related to senile plaques, whereas in dogs such progression is rare. We evaluated the composition of aged canine vessel amyloid and preamyloid both biochemically and immunohistochemically. The vessel amyloid extended mainly to residue 40 (Aβ40), while preamyloid contained a mixture of Aβ17-42 and Aβ42, with minimal Aβ40. Our results suggest other factors besides Aβ42 are important for neuritic plaque formation.
